Cathepsin D anticorps

N° du produit ABIN783842

Détail du produit anti-Cathepsin D anticorps

Antigène: Cathepsin D (CTSD)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cathepsin D est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Specificité: This antibody detects both the 52 kDa proform and the 34 kDa cleaved fragment of Cathepsin D.

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse, Rat.

Purification: Affinity chromatography

Immunogène: Synthetic peptide surrounding amino acid 140 of mouse cathepsins D

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS, pH 7.2, 0.01 % Thimerosal, 30 % Glycerol, 0.5 % BSA

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Upon receipt, store (in aliquots) at -20 to -70 °C.

Détails sur Cathepsin D

Antigène: Cathepsin D (CTSD)

Autre désignation: Cathepsin D (CTSD Produits)

Synonymes: anticorps catD, anticorps fb93e11, anticorps fj17b09, anticorps wu:fb93e11, anticorps wu:fj17b09, anticorps LOC398557, anticorps Cathd, anticorps CatD, anticorps LOC100136761, anticorps CTSD, anticorps DKFZp469J0315, anticorps DDBDRAFT_0205785, anticorps DDBDRAFT_0215012, anticorps DDB_0205785, anticorps DDB_0215012, anticorps CLN10, anticorps CPSD, anticorps CD, anticorps cathepsin D, anticorps cathepsin D S homeolog, anticorps lysosomal aspartic protease, anticorps cathepsin D-like, anticorps ctsd, anticorps LOC398557, anticorps ctsd.S, anticorps CatD, anticorps LOC5567565, anticorps LOC100136761, anticorps CTSD, anticorps Cathd, anticorps ctsD, anticorps catd, anticorps Ctsd, anticorps LOC443060

Sujet: Cathepsin D is a normal lysosomal protease that is expressed in all cells. It is an aspartyl protease with a pH optimum in the range of 3-5, and contains two N-linked oligosaccharides. Cathepsin D is synthesized as an inactive 52 kDa pro-enzyme. Activation involves the proteolytic removal of the 43 amino acid profragment and an internal cleavage to generate the two-chain form made up of 34 and 14 kDa subunits. Cathepsin D contains the mannose-6-phosphate lysosomal localization signal that targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins. In certain tumor cells, Cathepsin D is abnormally processed and is secreted in its 52 kDa precursor form. Numerous clinical studies as well as in vitro evidence suggest that cathepsin D plays an important role in malignant transformation and may be a useful prognostic indicator for breast cancer.Synonyms: CPSD, CTSD

ID gène: 1509

NCBI Accession: NP_001900

UniProt: P07339

Pathways: Peptide Hormone Metabolism