ERP44 anticorps (Internal Region)

N° du produit ABIN784030

Détail du produit anti-ERP44 anticorps

Antigène: ERP44 (Endoplasmic Reticulum Protein 44 (ERP44))

Épitope: Internal Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERP44 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody reacts to the internal region of ERP44 / TXNDC4.

Purification: Immunoaffinity chromatography

Immunogène: ERP44 antibody was raised against internal domain of human.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: PBS containing 0.09 % sodium azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur ERP44

Antigène: ERP44 (Endoplasmic Reticulum Protein 44 (ERP44))

Autre désignation: TXNDC4 / ERP44 (ERP44 Produits)

Synonymes: anticorps PDIA10, anticorps TXNDC4, anticorps 1110001E24Rik, anticorps AI849526, anticorps AL033348, anticorps Txndc4, anticorps BWK4, anticorps txndc4, anticorps zgc:77883, anticorps endoplasmic reticulum protein 44, anticorps ERP44, anticorps Erp44, anticorps erp44

Sujet: TXNDC4/ERp44/KIAA0573 was identified via its interaction with Erol-Lalpha, which in turn has been shown to regulate oxidative protein folding by selectively oxidizing protein disulfide isomerase. TXNDC4 is induced during ER stress and forms mixed disulfides with both hEROs and cargo folding intermediates. Over expression has been shown to alter the equilibrium of the different Ero1-Lalpha redox isoforms suggesting that TXNDC4 may be involved in the control of oxidative protein folding. It has also been suggested that TXNDC4 senses the environment in the ER lumen because it modulates IP3R1 (1,4,5-triphosphate receptor type 1) activity thereby regulating cytosolic calcium concentrations and intraluminal conditions.Synonyms: Endoplasmic reticulum resident protein ERp44, KIAA0573, Thioredoxin domain-containing protein 4

ID gène: 23071

NCBI Accession: NP_055866

Pathways: Cell RedoxHomeostasis, SARS-CoV-2 Protein Interactome