GRIN2C anticorps (pSer1096)

N° du produit ABIN784607

L’anticorps anti-GRIN2C Polyclonal Lapin est utilisé pour la détection de GRIN2C dans des échantillons de Humain, Souris, Rat, Boeuf (Vache), Chien et Non-Human Primate. Il a été validé pour WB.

Aperçu rapide pour GRIN2C anticorps (pSer1096) (ABIN784607)

Antigène: GRIN2C (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Non-Human Primate

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRIN2C est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-GRIN2C anticorps

Épitope: pSer1096

Specificité: Specific for the ~140k NR2C subunit of the NMDA receptor phosphorylated at Ser1096. Immunolabeling is blocked by preadsorption of antibody with the phospho-peptide that was used to generate the antibody but not by the corresponding dephospho-peptide.

Réactivité croisée (Details): Species reactivity (expected):Bovine, Canine, Human and non-Human primates.
Species reactivity (tested):Mouse and Rat.

Purification: Affinity Chromatography

Immunogène: Synthetic phospho-peptide surrounding the phospho Ser1096 of the NR2C-subunit of Rat NMDA receptor.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at -20 °C.

Détails sur GRIN2C

Antigène: GRIN2C (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C))

Autre désignation: NMDA Receptor 2C

Sujet: The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002, Wenthold et al., 2003, Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989, Alvestad et al., 2003, Snell et al., 1996). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999). The NR2C subunit of the receptor is thought to influence the NMDAR conductance level (Ebralidze et al., 1996). Phosphorylation of Ser1096 by PKB on NR2C has been recently demonstrated to regulate NMDA receptor binding to 14-3-3 (Chen & Roche 2009)Synonyms: GRIN2C, Glutamate [NMDA] receptor subunit epsilon-3, N-methyl D-aspartate receptor subtype 2C, NMDAR2C, NR2C

ID gène: 24411

NCBI Accession: NP_036707

Pathways: Synaptic Membrane