BMI1 anticorps (Internal Region)

N° du produit ABIN789019

Cet anticorps Lapin Polyclonal détecte spécifiquement BMI1 dans WB, IF et ICC. Il présente une réactivité envers Humain, Souris, Rat, Lapin, Chien, Boeuf (Vache), Poulet, Poisson zèbre (Danio rerio) et Protozoa.

Aperçu rapide pour BMI1 anticorps (Internal Region) (ABIN789019)

Antigène: BMI1 (BMI1 Polycomb Ring Finger Oncogene (BMI1))

Reactivité: Humain, Souris, Rat, Lapin, Chien, Boeuf (Vache), Poulet, Poisson zèbre (Danio rerio), Protozoa

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BMI1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-BMI1 anticorps

Épitope: AA 1-100, Internal Region

Réactivité croisée: Boeuf (Vache), Chien, Poulet, Chat, Humain, Souris, Primate, Lapin, Rat (Rattus)

Purification: affinity purified

Immunogène: A synthetic peptide made to an internal region (within AA 1-100) of the human Bmi1 protein. [Swiss-Prot# P35226].

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Stock: -20 °C

Détails sur BMI1

Antigène: BMI1 (BMI1 Polycomb Ring Finger Oncogene (BMI1))

Autre désignation: Bmi1

Sujet: Bmi1 induces telomerase activity and immortalizes human mammary epithelial cells. Bmi1 extends the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway. It has also been termed an oncogene with aberrant expression in various carcinomas. It has been shown to be a negative regulator of p19Arf, Ink4a (p14Arf) and tp53 known tumor repressors. Ablation of Bmi1 is required for short term survival of cancer cells. In addition, Bmi1 expression promotes HSC self-renewal. These findings highlight the importance of epigenetic regulation in HSC self-renewal and identify PcG genes as potential targets for therapeutic HSC manipulation.

UniProt: P35226

Pathways: Cycle Cellulaire, Autophagy