HSF1 anticorps (pSer307)

N° du produit ABIN800973

Cet anticorps anti-HSF1 Polyclonal Lapin (ABIN800973) détecte spécifiquement HSF1 dans WB, IHC (p), IF (p), IF (cc) et IHC (fro). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour HSF1 anticorps (pSer307) (ABIN800973)

Antigène: HSF1 (Heat Shock Factor Protein 1 (HSF1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HSF1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-HSF1 anticorps

Épitope: pSer307

Fonction: phospho-HSF1 (Ser307) Polyclonal Antibody

Réactivité croisée: Souris

Homologie: Human

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human HSF1 around the phosphorylation site of Ser303

Isotype: IgG

Information d'application

Indications d'application: WB(1:300-5000),

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur HSF1

Antigène: HSF1 (Heat Shock Factor Protein 1 (HSF1))

Autre désignation: HSF1

Sujet:

Synonyms: HSF1 Ser307, Heat shock factor 1, Heat shock factor protein 1, Heat shock transcription factor 1, HSF 1, hsf1, HSTF 1, HSTF1, HSF1_HUMAN.

Background: Two HSFs have been identified in human cells, HSF 1 and HSF 2, which bind to the same HSEs and have 38 % sequence identity. These factors are activated by distinct stimuli, HSF 1 is responsive to classical stress signals such as heat, heavy metals and oxidative reagents, whereas HSF 2 is activated during hemin-mediated differentiation of human erythroleukemia cells.HSF 1 exists constitutively in the cytoplasm and the nucleus of unstressed cells as a monomer which lacks DNA binding activity. Through an unknown signal generated during stress, HSF 1 becomes activated to a nuclear localized, trimeric state which binds to DNA. The phosphorylation of HSF 1 is necessary for maximal transcription of heat shock genes.

ID gène: 3297