MST1R anticorps (pTyr1353)

N° du produit ABIN872300

L’anticorps anti-MST1R Polyclonal Lapin est utilisé pour la détection de MST1R dans des échantillons de Humain. Il a été validé pour WB, FACS, IHC (p), IF (cc), IF (p) et IHC (fro).

Aperçu rapide pour MST1R anticorps (pTyr1353) (ABIN872300)

Antigène: MST1R (Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MST1R est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-MST1R anticorps

Épitope: pTyr1353

Fonction: phospho-MST1R (Tyr1353) Polyclonal Antibody

Réactivité croisée: Humain

Homologie: Mouse,Rat,Dog,Pig,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human MST1R around the phosphorylation site of Tyr1353

Isotype: IgG

Information d'application

Indications d'application: WB(1:300-5000),

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur MST1R

Antigène: MST1R (Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R))

Autre désignation: MST1R

Sujet:

Synonyms: p-MST1RTyr1353, RON phospho Y1353, MST1Rphospho S1349, c met related tyrosine kinase, CD136 antigen, CDw136, Macrophage stimulating 1 receptor, Macrophage stimulating protein receptor alpha chain, MACROPHAGE STIMULATING PROTEIN RECEPTOR, Macrophage stimulating protein receptor beta chain, MSP receptor, MST1R, p185 RON, PTK 8, ptk8, PTK8 protein tyrosine kinase 8, RON, RON protein tyrosine kinase, Stem cell derived tyrosine kinase.

Background: MST1R/Ron, a HGF Receptor/MET-type protein kinase, mediates the biological activities of macrophage-stimulating protein (MSP), a multifunctional cytokine that regulates cell adhesion, motility, growth, and survival. The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain. In knockout studies, MST1R/RON (-/-) mice failed to survive past the periimplantation period. The MST1R/RON gene has been mapped to 3p21, a region of frequent deletion or mutation in small cell lung and renal carcinoma, and has been implicated in the progression of several epithelial cancers. Ron expression has been documented in many normal human tissues. ESTs have been isolated from several tissue libraries, including normal colon, mouth, prostate, and testis and cancerous colon, prostate, stomach, and uterus.

ID gène: 4486

Pathways: Signalisation RTK