RPS3 anticorps (AA 101-200)

N° du produit ABIN872550

Détail du produit anti-RPS3 anticorps

Antigène: RPS3 (Ribosomal Protein S3 (RPS3))

Épitope: AA 101-200

Reactivité: Humain, Souris, Xenopus laevis

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RPS3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Souris, Xenopus laevis

Homologie: Rat,Zebrafish

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human RPS3

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur RPS3

Antigène: RPS3 (Ribosomal Protein S3 (RPS3))

Autre désignation: RPS3 (RPS3 Produits)

Synonymes: anticorps S3, anticorps D7Ertd795e, anticorps Rs_3, anticorps fb13d09, anticorps wu:fb13d09, anticorps zgc:56088, anticorps ribosomal protein S1a, anticorps rps3, anticorps 6779, anticorps CG6779, anticorps DmRpS3, anticorps Dmel\\CG6779, anticorps M(3)124, anticorps M(3)95A, anticorps M(3)B, anticorps M(3)B2, anticorps M(3)Fla, anticorps M(3)w, anticorps M(3R)w, anticorps M95A, anticorps M[[w]], anticorps Mw, anticorps RPS3, anticorps RS3, anticorps Rp S3, anticorps RpS, anticorps Rps3, anticorps X72921, anticorps dS3, anticorps rpS3, anticorps rpls1b, anticorps rpls3-b, anticorps ribosomal protein S3, anticorps 40S ribosomal protein S3, anticorps ribosomal protein S3 L homeolog, anticorps Ribosomal protein S3, anticorps 30S ribosomal protein S3, anticorps ribosomal protein S3 S homeolog, anticorps RPS3, anticorps Rps3, anticorps rps-3, anticorps rps3, anticorps rps3.L, anticorps RpS3, anticorps rps3.S

Sujet:

Synonyms: S3, 40S ribosomal protein S3, RPS3, OK/SW-cl.26

Background: Involved in translation as a component of the 40S small ribosomal subunit (PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408).

ID gène: 6188

UniProt: P23396

Pathways: Positive Regulation of Endopeptidase Activity