PARP3 anticorps (AA 301-400)

N° du produit ABIN873020

L’anticorps Lapin Polyclonal anti-PARP3 a été validé pour ELISA, WB, IF (cc), IF (p), IHC (p) et IHC (fro). Il convient pour détecter PARP3 dans des échantillons de Souris.

Aperçu rapide pour PARP3 anticorps (AA 301-400) (ABIN873020)

Antigène: PARP3 (Poly (ADP-Ribose) Polymerase Family, Member 3 (PARP3))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PARP3 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-PARP3 anticorps

Épitope: AA 301-400

Réactivité croisée: Souris

Homologie: Human,Rat,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human PARP3

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Détails sur PARP3

Antigène: PARP3 (Poly (ADP-Ribose) Polymerase Family, Member 3 (PARP3))

Autre désignation: PARP3

Sujet:

Synonyms: hPARP3, IRT1, NAD+ ADP ribosyltransferase 3, pADPRT 3, Poly[ADP ribose] synthetase 3, ADP ribosyltransferase NAD+, poly ADP ribose, ADPRT-3, ADPRT3, ADPRTL2, ADPRTL3, hPARP 3, hPARP-3, IRT 1, IRT1, NAD+ ADP-ribosyltransferase 3, NAD+ ADP ribosyltransferase 3, pADPRT-3, pADPRT3, PARP 3, PARP-3, PARP3, Poly ADP ribose polymerase family, member 3, Poly ADP ribose synthetase 3, Poly [ADP-ribose] polymerase 3, Poly[ADP-ribose] synthase 3.

Background: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.Tissue specificity: Widely expressed, the highest levels are in the kidney, skeletal muscle, liver, heart and spleen, also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus.

ID gène: 10039