BID anticorps (pSer61) (AbBy Fluor® 350)

N° du produit ABIN876653

L’anticorps Lapin Polyclonal anti-BID a été validé pour WB, FACS, IF (cc) et IF (p). Il convient pour détecter BID dans des échantillons de Humain.

Aperçu rapide pour BID anticorps (pSer61) (AbBy Fluor® 350) (ABIN876653)

Antigène: BID (BH3 Interacting Domain Death Agonist (BID))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BID est conjugé à/à la AbBy Fluor® 350

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-BID anticorps (AbBy Fluor® 350)

Épitope: pSer61

Réactivité croisée: Humain

Homologie: Mouse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from mouse Bid around the phosphorylation site of Ser61

Isotype: IgG

Information d'application

Indications d'application: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur BID

Antigène: BID (BH3 Interacting Domain Death Agonist (BID))

Autre désignation: Bid

Sujet:

Synonyms: Bid phospho S61, p-Bid phospho S61, BH3 interacting domain death agonist, p22 BID, BID, BH3-interacting domain death agonist, AltName: BH3-interacting domain death agonist p15, BH3-interacting domain death agonist p13, p13 BID, BH3-interacting domain death agonist p11, p11 BID.

Background: Bid, a BH3 domain containing proapoptotic Bcl2 family member, is localized in the cytosolic fraction of cells as an inactive precursor. Its active form is generated upon proteolytic cleavage by caspase 8 in the Fas signaling pathway. Cleaved Bid translocates to mitochondria and releases its potent proapoptotic activity, which in turn induces cytochrome c release and mitochondrial damage. The cytochrome c releasing activity of Bid was antagonized by Bcl2. Mutation in the SH3 domain can diminish the cytochrome c releasing activity. In animal model studies, Bid deficient mice are found resistant to the lethal effects of death factor signals relayed through Fas.

ID gène: 12122

Pathways: Apoptose, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity