Desmin anticorps (pThr76, pThr77) (AbBy Fluor® 350)

N° du produit ABIN878522

L’anticorps Lapin Polyclonal anti-Desmin a été validé pour FACS. Il convient pour détecter Desmin dans des échantillons de Humain.

Aperçu rapide pour Desmin anticorps (pThr76, pThr77) (AbBy Fluor® 350) (ABIN878522)

Antigène: Desmin (DES)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Desmin est conjugé à/à la AbBy Fluor® 350

Application: Flow Cytometry (FACS)

Détail du produit anti-Desmin anticorps (AbBy Fluor® 350)

Épitope: pThr76, pThr77

Réactivité croisée: Humain

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human DES around the phosphorylation site of Thr76/Thr77

Isotype: IgG

Information d'application

Indications d'application: FCM 1:20-100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur Desmin

Antigène: Desmin (DES)

Autre désignation: Desmin +

Sujet:

Synonyms: Desmin phospho T76/77, Desmin phospho Thr76/Thr77, Desmin phospho Thr76+Thr77, p-Desmin Thr76/Thr77, CMD1I, CSM1, CSM2, DES, FLJ12025, FLJ39719, FLJ41013, FLJ41793, Intermediate filament protein, OTTHUMP00000064865, DESM_HUMAN, Desmin, FLJ12025, FLJ39719, FLJ41013, FLJ41793.

Background: filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z line structures. Defects in Desmin are the cause of desmin related cardio skeletal myopathy (CSM) also known as desmin related myopathy (DRM). CSM is characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure, and by intracytoplasmic accumulation of desmin reactive deposits in cardiac and skeletal muscle cells. A desmin related myopathy can have a distal onset, it is then known as hereditary distal myopathy (HDM). Defects in Desmin are also the cause of dilated cardiomyopathy type 1I (CMD1I). CMD1I is an autosomal form of dilated cardiomyopathy characterized by ventricular dilatation and impaired systolic function. Antidesmin are useful in identification of tumours of myogenic origin.

ID gène: 1674