CDK5 anticorps (pTyr15) (HRP)

N° du produit ABIN879032

Détail du produit anti-CDK5 anticorps (HRP)

Antigène: CDK5 (Cyclin-Dependent Kinase 5 (CDK5))

Épitope: pTyr15

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDK5 est conjugé à/à la HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Souris, Rat

Homologie: Cow,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human CDK5 around the phosphorylation site of Tyr15

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Conseil sur la manipulation: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur CDK5

Antigène: CDK5 (Cyclin-Dependent Kinase 5 (CDK5))

Autre désignation: CDK5 (CDK5 Produits)

Synonymes: anticorps PSSALRE, anticorps AW048668, anticorps Crk6, anticorps CDK5, anticorps CG8203, anticorps DmCdk5, anticorps Dmel\\CG8203, anticorps cdk5, anticorps zgc:101604, anticorps cyclin dependent kinase 5, anticorps cyclin-dependent kinase 5, anticorps Cyclin-dependent kinase 5, anticorps cyclin-dependent kinase 5 L homeolog, anticorps Cyclin-dependent-like kinase 5, anticorps CDK5, anticorps Cdk5, anticorps cdk5, anticorps cdk5.L, anticorps cdk-5

Sujet:

Synonyms: Cdk5 phospho Y15, p-Cdk5Y15, Cdk 5, Cell division protein kinase 5, Crk6, Cyclin dependent kinase 5, Protein kinase CDK5 splicing, PSSALRE, Serine threonine protein kinase PSSALRE, Tau protein kinase II catalytic subunit, TPKII catalytic subunit, CDK5_HUMAN.

Background: CDK5 (Cyclin Dependent Kinase 5) is serine/threonine kinase involved in synaptic regulation and neuronal development, phosphorylates synaptic protein Pctaire1, regulates acetylcholine receptor expression. CDK5 is a member of the cyclindependent kinase family of serine/threonine kinases. It is present in numerous mammalian tissues including kidney, testes, and ovary. Its activity is detected almost exclusively in brain extracts. Neuronal and muscle cells contain the highest amount of this protein. Similar to other Cdks, monomeric Cdk5 displays no enzymatic activity, but Cdk5 is not activated by cyclins. Instead, the p35 protein, which is expressed solely in the brain, activates Cdk5. Cdk5 interacts with D1 and D3 type G1 cyclins and can phosphorylate histone H1, TAU, MAP2 and NF-H and NF-M. Cdk5 activity is involved in terminal differentiation of neurons and muscle cells.

ID gène: 1020

Pathways: Cycle Cellulaire, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development, Synaptic Vesicle Exocytosis