Caveolin 2 anticorps (AbBy Fluor® 647)

N° du produit ABIN886835

L’anticorps anti-Caveolin 2 Polyclonal Lapin est utilisé pour la détection de Caveolin 2 dans des échantillons de Humain. Il a été validé pour IF.

Aperçu rapide pour Caveolin 2 anticorps (AbBy Fluor® 647) (ABIN886835)

Antigène: Caveolin 2 (CAV2)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Caveolin 2 est conjugé à/à la AbBy Fluor® 647

Application: Immunofluorescence (IF)

Détail du produit anti-Caveolin 2 anticorps (AbBy Fluor® 647)

Fonction: Caveolin-2 Polyclonal Antibody, AbBy Fluor-647 Conjugated

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Caveolin-2

Isotype: IgG

Information d'application

Indications d'application: IF(IF=1:100-500)

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur Caveolin 2

Antigène: Caveolin 2 (CAV2)

Autre désignation: Caveolin-2

Sujet:

Synonyms: CAV, CAV2, CAV2_HUMAN, Caveolae protein 20 kD, Caveolin 2, Caveolin2, Caveolin 2 isoform a and b, Caveolin 2 isoform c, Caveolin-2, MGC12294.

Background: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression.Tissue specificity: Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts.Cellular localization: Nucleus. Cytoplasm. Golgi apparatus membrane. Cell membrane. Membrane > caveola. Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27-phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments.

ID gène: 858

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development