PARP3 anticorps (AA 301-400) (Biotin)

N° du produit ABIN910116

Cet anticorps anti-PARP3 est un anticorps Lapin Polyclonal détectant PARP3 dans ELISA, WB, IHC (p) et IHC (fro). Adapté pour Souris.

Aperçu rapide pour PARP3 anticorps (AA 301-400) (Biotin) (ABIN910116)

Antigène: PARP3 (Poly (ADP-Ribose) Polymerase Family, Member 3 (PARP3))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PARP3 est conjugé à/à la Biotin

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-PARP3 anticorps (Biotin)

Épitope: AA 301-400

Réactivité croisée: Souris

Homologie: Human,Rat,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human PARP3

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur PARP3

Antigène: PARP3 (Poly (ADP-Ribose) Polymerase Family, Member 3 (PARP3))

Autre désignation: PARP3

Sujet:

Synonyms: hPARP3, IRT1, NAD+ ADP ribosyltransferase 3, pADPRT 3, Poly[ADP ribose] synthetase 3, ADP ribosyltransferase NAD+, poly ADP ribose, ADPRT-3, ADPRT3, ADPRTL2, ADPRTL3, hPARP 3, hPARP-3, IRT 1, IRT1, NAD+ ADP-ribosyltransferase 3, NAD+ ADP ribosyltransferase 3, pADPRT-3, pADPRT3, PARP 3, PARP-3, PARP3, Poly ADP ribose polymerase family, member 3, Poly ADP ribose synthetase 3, Poly [ADP-ribose] polymerase 3, Poly[ADP-ribose] synthase 3.

Background: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.Tissue specificity: Widely expressed, the highest levels are in the kidney, skeletal muscle, liver, heart and spleen, also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus.

ID gène: 10039