PHGDH anticorps (AA 101-200) (Cy7)

N° du produit ABIN910987

Détail du produit anti-PHGDH anticorps (Cy7)

Antigène: PHGDH (phosphoglycerate Dehydrogenase (PHGDH))

Épitope: AA 101-200

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PHGDH est conjugé à/à la Cy7

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human PHGDH

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur PHGDH

Antigène: PHGDH (phosphoglycerate Dehydrogenase (PHGDH))

Autre désignation: PHGDH (PHGDH Produits)

Synonymes: anticorps fb38f06, anticorps zgc:65956, anticorps wu:fb38f06, anticorps embryo sac development arrest 9, anticorps F10M10.7, anticorps ECK2909, anticorps JW2880, anticorps 3-PGDH, anticorps 3PGDH, anticorps 4930479N23, anticorps A10, anticorps PGAD, anticorps PGD, anticorps PGDH, anticorps SERA, anticorps PDG, anticorps phosphoglycerate dehydrogenase, anticorps D-3-phosphoglycerate dehydrogenase, anticorps 3-phosphoglycerate dehydrogenase, anticorps phgdh, anticorps EDA9, anticorps serA, anticorps Sthe_2284, anticorps Dacet_1260, anticorps Mrub_0173, anticorps MMAH_RS07650, anticorps Arnit_0487, anticorps Ndas_0174, anticorps Mesil_2386, anticorps Slip_0010, anticorps Trad_0302, anticorps Acear_0027, anticorps Mahau_0665, anticorps MZHIL_RS05165, anticorps Mesop_1331, anticorps Thein_0855, anticorps Phgdh, anticorps PHGDH

Sujet:

Synonyms: NLS, PDG, PGD, NLS1, PGAD, PGDH, SERA, 3PGDH, 3-PGDH, PHGDHD, HEL-S-113, D-3-phosphoglycerate dehydrogenase, PHGDH, PGDH3

Background: The survival and development of central neurons require the supply of trophic factors by glial cells. The trophic actions of glial cells on Purkinje neurons are mediated by L-serine and glycine, which are glia-derived trophic factors synthesized by 3PGDH (1). 3PGDH protein is 544 amino acids in length. Two distinct mRNA transcripts that encode for 3PGDH protein in normal human tissues are dominant 2.1 kb mRNA, which is highly expressed in prostate, testis, ovary, brain, liver, kidney, and pancreas, and weakly expressed in thymus, colon, and heart, and 710 bp mRNA, which is highly expressed in heart and skeletal muscle (2). 3PGDH is regulated at the transcriptional level depending on tissue specificity and cellular proliferative status (2). 3PGDH protein is also highly expressed in adult and fetal brain tissues (3). 3PGDH protein plays an important role in the metabolism, development, and function of the central nervous system (3) and its deficiency is a treatable congential error (4-5) that impairs L-serine biosynthesis which is characterized by congenital microcephaly, psychomotor retardation, and seizures (3).

ID gène: 26227

UniProt: O43175

Pathways: Metabolism of Steroid Hormones and Vitamin D, L'effet Warburg