TLR5 anticorps (C-Term)

N° du produit ABIN920613

Cet anticorps anti-TLR5 Polyclonal Lapin (ABIN920613) détecte spécifiquement TLR5 dans WB et ICC. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour TLR5 anticorps (C-Term) (ABIN920613)

Antigène: TLR5 (Toll-Like Receptor 5 (TLR5))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TLR5 est non-conjugé

Application: Western Blotting (WB), Immunocytochemistry (ICC)

Détail du produit anti-TLR5 anticorps

Épitope: C-Term

Attributs du produit: Positive Control: Found in the membrane, TLR5 is highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis.

Purification: Antigen Immunoaffinity purified

Immunogène: Rabbit polyclonal TLR5 antibody was raised against a peptide corresponding to 15 amino acids near the carboxy terminus of TLR5.

Isotype: IgG

Information d'application

Indications d'application: Western blot: use at 1-2 µg/mL. Immunocytochemistry: use at 10 µg/mL

Restrictions: For Research Use only

Stockage

Buffer: Phosphate buffered saline with 0.02% sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur TLR5

Antigène: TLR5 (Toll-Like Receptor 5 (TLR5))

Sujet: Toll-like receptors (TRLs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR5 recognizes flagellin from both Gram-positive and Gram-negative bacteria and will cause the activation of NF-B, leading to the activation of TNF-alpha and other cytokines. A common TLR5 stop codon polymorphism that disrupts TLR5 signaling is associated with susceptibility to Legionnaires' disease and demonstrates the importance of TLR5 in the innate immune response. Synonyms:

Poids moléculaire: 97.8 kDa

Pathways: Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades