DFFA anticorps (N-Term)

N° du produit ABIN925765

Cet anticorps Lapin Polyclonal détecte spécifiquement DFFA dans WB. Il présente une réactivité envers Humain et Rat.

Aperçu rapide pour DFFA anticorps (N-Term) (ABIN925765)

Antigène: DFFA (DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DFFA est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-DFFA anticorps

Épitope: N-Term

Réactivité croisée: Rat (Rattus)

Immunogène: DFFA antibody was raised in rabbit using the N terminal of DFFA as the immunogen

Information d'application

Indications d'application: WB: 5 µg/mL
Optimal conditions should be determined by the investigator.

Commentaires:

DFFA Blocking Peptide, (ABIN5613183), is also available for use as a blocking control in assays to test for specificity of this DFFA antibody

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 100 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Détails sur DFFA

Antigène: DFFA (DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA))

Autre désignation: DFFA

Sujet: Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Synonyms: Polyclonal DFFA antibody, Anti-DFFA antibody, DNA fragmentation factor, 45kDa, alpha polypeptide antibody, DFF-45 antibody, DFF1 antibody, Ion ChannelAD antibody.

Pathways: Apoptose, Caspase Cascade in Apoptosis