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CD147 anticorps (Biotin)

BSG Reactivité: Humain WB, FACS, IHC (p), IP Hôte: Souris Monoclonal MEM-M6-1 Biotin
N° du produit ABIN93982
  • Antigène Voir toutes CD147 (BSG) Anticorps
    CD147 (BSG) (Basigin (Ok Blood Group) (BSG))
    Reactivité
    • 144
    • 43
    • 41
    • 17
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 81
    • 75
    • 7
    Souris
    Clonalité
    • 92
    • 70
    Monoclonal
    Conjugué
    • 84
    • 13
    • 11
    • 10
    • 7
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CD147 est conjugé à/à la Biotin
    Application
    • 94
    • 85
    • 36
    • 35
    • 31
    • 26
    • 15
    • 14
    • 13
    • 10
    • 9
    • 9
    • 9
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)
    Specificité
    The antibody MEM-M6/1 recognizes an extracellular epitope in the N-terminal Ig domain (D1) of CD147 (Neurothelin), a 50-60 kDa type I transmembrane glycoprotein primarily expressed on all leukocytes, red blood cells, platelets and endothelial cells, it is not expressed by resting lymphocytes. The antibody MEM-M6/1 is a high-affinity antibody capable of binding to unstimulated peripheral blood T cells.
    Réactivité croisée (Details)
    Human
    Purification
    Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography.
    Immunogène
    Protein A-CR purified soluble recombinant form of CD147, CD147Rg, which consists of the cDNA coding for the hinge region, CH2-and CH3 domain of human IgG1 (CD147Rg is secreted by transfectants as a dimer).
    Clone
    MEM-M6-1
    Isotype
    IgG1
    Top Product
    Discover our top product BSG Anticorps primaire
  • Indications d'application
    Flow cytometry: Recommended dilution: 8 μg/mL.
    Commentaires

    The purified antibody is conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.

    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Avoid prolonged exposure to light.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Do not freeze.
  • Schatzlmaier, Supper, Göschl, Zwirzitz, Eckerstorfer, Ellmeier, Huppa, Stockinger: "Rapid multiplex analysis of lipid raft components with single-cell resolution." dans: Science signaling, Vol. 8, Issue 395, pp. rs11, (2015) (PubMed).

    Koch, Staffler, Hüttinger, Hilgert, Prager, Cerný, Steinlein, Majdic, Horejsí, Stockinger: "T cell activation-associated epitopes of CD147 in regulation of the T cell response, and their definition by antibody affinity and antigen density." dans: International immunology, Vol. 11, Issue 5, pp. 777-86, (1999) (PubMed).

  • Antigène
    CD147 (BSG) (Basigin (Ok Blood Group) (BSG))
    Autre désignation
    CD147 (BSG Produits)
    Synonymes
    anticorps EMMPRIN, anticorps RPE7, anticorps 5F7, anticorps CD147, anticorps M6, anticorps OK, anticorps TCSF, anticorps AI115436, anticorps AI325119, anticorps HT-7, anticorps 5A11, anticorps CE9, anticorps HT7, anticorps Ox47R, anticorps basignin, anticorps wu:fb26a05, anticorps wu:fo98e12, anticorps bsg, anticorps prso03, anticorps basigin (Ok blood group), anticorps basigin, anticorps basigin (Ok blood group) S homeolog, anticorps BSG, anticorps Bsg, anticorps bsg, anticorps bsg.S
    Sujet
    Basigin (Ok blood group),CD147 (basigin, neurothelin, OX-47, 5A11, CE9, M6) also known as EMMPRIN (extracellular matrix metalloproteinase inducer) or TCSF (tumour cell-derived collagenase-stimulatory factor) is an ubiquitously expressed cell surface protein with multiple glycosylated forms. The highest level of CD147 expression is on metabolically active cells, such as lymphoblasts, inflammatory cells, brown adipocytes and malignant tumour cells. CD147 has multiple functions, including facilitating of cell surface expression of monocarboxylate transporter proteins and extracellular matrix metalloproteinases, regulation of integrin functions, it plays roles in cell development and activation, fetal development or retinal function.,Neurothelin, Basigin, LAM6, CSF, 5F7, TCSF, BSG, TCSF, Emprin, OK blood group
    ID gène
    682
    UniProt
    P35613
    Pathways
    S100 Proteins
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