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IGF2R anticorps

IGF2R Reactivité: Humain, Non-Human Primate WB, FACS, IP Hôte: Souris Monoclonal MEM-238 unconjugated
N° du produit ABIN94039
  • Antigène Voir toutes IGF2R Anticorps
    IGF2R (Insulin-Like Growth Factor 2 Receptor (IGF2R))
    Reactivité
    • 90
    • 36
    • 19
    • 8
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    Humain, Non-Human Primate
    Hôte
    • 69
    • 26
    Souris
    Clonalité
    • 67
    • 28
    Monoclonal
    Conjugué
    • 48
    • 6
    • 6
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp IGF2R est non-conjugé
    Application
    • 36
    • 36
    • 28
    • 24
    • 16
    • 13
    • 13
    • 12
    • 9
    • 6
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP)
    Specificité
    The antibody MEM-238 recognizes an extracellular epitope between amino acids 192-697 of CD222 (IGF2 receptor), a ubiquitously expressed 250 kDa multifunctional type I transmembrane protein. The majority of CD222 is found in the late endosomal/prelysosomal compartment, 5-10 % in the plasma membrane and the truncated (220 kDa) form of CD222 is present in human and bovine serum.
    Réactivité croisée (Details)
    Human, Non-Human Primates
    Purification
    Purified by protein-A affinity chromatography.
    Pureté
    > 95 % (by SDS-PAGE)
    Immunogène
    Recombinant Vaccinia virus encoding CD222.
    Clone
    MEM-238
    Isotype
    IgG1
  • Indications d'application
    Flow cytometry: Extracellular and intracellular staining. Recommended dilution: 2-6 μg/mL.
    Western blotting: Non-reducing conditions.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Do not freeze.
  • Schatzlmaier, Supper, Göschl, Zwirzitz, Eckerstorfer, Ellmeier, Huppa, Stockinger: "Rapid multiplex analysis of lipid raft components with single-cell resolution." dans: Science signaling, Vol. 8, Issue 395, pp. rs11, (2015) (PubMed).

    Leksa, Godár, Cebecauer, Hilgert, Breuss, Weidle, Horejsí, Binder, Stockinger: "The N terminus of mannose 6-phosphate/insulin-like growth factor 2 receptor in regulation of fibrinolysis and cell migration." dans: The Journal of biological chemistry, Vol. 277, Issue 43, pp. 40575-82, (2002) (PubMed).

  • Antigène
    IGF2R (Insulin-Like Growth Factor 2 Receptor (IGF2R))
    Autre désignation
    CD222 (IGF2R Produits)
    Synonymes
    anticorps CD222, anticorps CIMPR, anticorps M6P-R, anticorps MPR1, anticorps MPRI, anticorps AI661837, anticorps CI-MPR, anticorps M6P/IGF2R, anticorps Mpr300, anticorps mpri, anticorps cd222, anticorps cimpr, anticorps m6p-r, anticorps insulin like growth factor 2 receptor, anticorps insulin-like growth factor 2 receptor, anticorps IGF2R, anticorps Igf2r, anticorps igf2r
    Sujet
    Insulin like growth factor 2 receptorprovided,CD222 (CIMPR, cation-independent mannose 6-phosphate receptor, IGF2 receptor) is a ubiquitously expressed 250 kDa transmembrane protein. No more than 10 % of CD222 is present on the cell surface where it serves as a multifunctional receptor. Intracellular (major) fraction of CD222 is involved in transport of newly synthesized lysosomal enzymes modified by mannose 6-phosphate from Golgi apparatus to lysosomes. The cell surface CD222 binds and internalizes exogeneous mannose 6-phosphate-containing ligands. Importantly, CD222 is crutial for internalization and degradation of insulin-like growth factor 2, thus controling cell growth. CD222 also complexes CD87 (urokinase-type plasminogen-activator receptor), plasminogen and latent TGF-beta, last but not least CD222 serves as a receptor for heparanase and even for Listeria.,IGF2R, MPR1, CIMPR, MPR300, M6P-R
    ID gène
    3482
    UniProt
    P11717
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