CD33 anticorps

N° du produit ABIN94072

Cet anticorps Souris Monoclonal détecte spécifiquement CD33 dans FACS. Il présente une réactivité avec des échantillons de Humain et Non-Human Primate.Il a été cité dans 1 publication.

Aperçu rapide pour CD33 anticorps (ABIN94072)

Antigène: CD33

Reactivité: Humain, Non-Human Primate

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD33 est non-conjugé

Application: Flow Cytometry (FACS)

Clone: HIM3-4

Détail du produit anti-CD33 anticorps

Fonction: Anti-Hu CD33 Purified

Réactivité croisée (Details): Human, Non-Human Primates

Attributs du produit: The antibody HIM3-4 reacts with an extracellular epitope of CD33, a 67 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells, it is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Immunogène: NFMY-9s human cell line

Isotype: IgG1

Information d'application

Indications d'application: Flow cytometry: Recommended dilution: 1-5 μg/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-CD33 (ABIN94072)

McCormack, Muji?, Osdal, Bruserud, Gjertsen: "Multiplexed mAbs: a new strategy in preclinical time-domain imaging of acute myeloid leukemia." dans: Blood, Vol. 121, Issue 7, pp. e34-42, (2013) (PubMed).

Détails sur CD33

Antigène: CD33

Autre désignation: CD33

Sujet: CD33 Molecule,CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies, these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia.,SIGLEC3, p67

ID gène: 945

UniProt: P20138