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CD59 anticorps (FITC)

CD59 Reactivité: Humain FACS Hôte: Souris Monoclonal MEM-43 FITC
N° du produit ABIN94201
  • Antigène Voir toutes CD59 Anticorps
    CD59
    Reactivité
    • 138
    • 14
    • 9
    • 8
    • 5
    • 3
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 90
    • 69
    • 6
    • 4
    Souris
    Clonalité
    • 97
    • 69
    • 1
    Monoclonal
    Conjugué
    • 79
    • 21
    • 15
    • 13
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CD59 est conjugé à/à la FITC
    Application
    • 101
    • 70
    • 46
    • 41
    • 31
    • 28
    • 25
    • 15
    • 15
    • 14
    • 13
    • 12
    • 11
    • 11
    • 8
    • 3
    • 3
    • 3
    • 1
    • 1
    Flow Cytometry (FACS)
    Specificité
    The antibody MEM-43 reacts with well defined epitope (W40, R-53) on CD59 (Protectin), an 18-20 kDa glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed on the surface of all hematopoietic cells, it is widely present on cells in all tissues. This antibody does not compete with MEM-43/5, and has blocking activity.
    Réactivité croisée (Details)
    Human
    Purification
    Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogène
    Thymocytes and T lymphocytes
    Clone
    MEM-43
    Isotype
    IgG2a
    Top Product
    Discover our top product CD59 Anticorps primaire
  • Indications d'application
    Flow cytometry: The reagent is designed for analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
    Commentaires

    The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.

    Restrictions
    For Research Use only
  • Reconstitution
    No reconstitution is necessary.
    Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Avoid prolonged exposure to light.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Omidvar, Wang, Brennan, Longhi, Smith, Morgan: "Expression of glycosylphosphatidylinositol-anchored CD59 on target cells enhances human NK cell-mediated cytotoxicity." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 5, pp. 2915-23, (2006) (PubMed).

    Ilangumaran, Briol, Hoessli: "CD44 selectively associates with active Src family protein tyrosine kinases Lck and Fyn in glycosphingolipid-rich plasma membrane domains of human peripheral blood lymphocytes." dans: Blood, Vol. 91, Issue 10, pp. 3901-8, (1998) (PubMed).

    Stefanová, Horejsí, Ansotegui, Knapp, Stockinger: "GPI-anchored cell-surface molecules complexed to protein tyrosine kinases." dans: Science (New York, N.Y.), Vol. 254, Issue 5034, pp. 1016-9, (1991) (PubMed).

    Forsberg, Bazil, Stefanová, Schröder: "Gene for human CD59 (likely Ly-6 homologue) is located on the short arm of chromosome 11." dans: Immunogenetics, Vol. 30, Issue 3, pp. 188-93, (1989) (PubMed).

    Stefanová, Hilgert, Kristofová, Brown, Low, Horejsí: "Characterization of a broadly expressed human leucocyte surface antigen MEM-43 anchored in membrane through phosphatidylinositol." dans: Molecular immunology, Vol. 26, Issue 2, pp. 153-61, (1989) (PubMed).

  • Antigène
    CD59
    Autre désignation
    CD59 (CD59 Produits)
    Synonymes
    anticorps 16.3A5, anticorps 1F5, anticorps EJ16, anticorps EJ30, anticorps EL32, anticorps G344, anticorps HRF-20, anticorps HRF20, anticorps MAC-IP, anticorps MACIF, anticorps MEM43, anticorps MIC11, anticorps MIN1, anticorps MIN2, anticorps MIN3, anticorps MIRL, anticorps MSK21, anticorps p18-20, anticorps Cd59a, anticorps Cd59b, anticorps MACIP, anticorps CD59 molecule (CD59 blood group), anticorps CD59 molecule, anticorps CD59, anticorps Cd59
    Sujet
    CD59 Molecule,CD59 (protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). It is thus the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 associates with C5b-8 complex and thereby counteracts appropriate formation of cytolytic pore within the plasma membrane. CD59 is also an low-affinity ligand of human CD2 and causes T cell costimulation.,MACIF, MAC-IP, protectin, MIRL, HRF-20, HRF20, 1F5, MIN
    ID gène
    966
    UniProt
    P13987
    Pathways
    Système du Complément
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