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Transferrin Receptor anticorps (FITC)

TFRC Reactivité: Humain FACS Hôte: Souris Monoclonal MEM-75 FITC
N° du produit ABIN94223
  • Antigène Voir toutes Transferrin Receptor (TFRC) Anticorps
    Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))
    Reactivité
    • 195
    • 81
    • 28
    • 7
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    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 110
    • 108
    • 31
    • 1
    • 1
    Souris
    Clonalité
    • 155
    • 94
    • 1
    Monoclonal
    Conjugué
    • 111
    • 27
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    • 3
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    • 3
    • 3
    • 2
    • 2
    • 2
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    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
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    Cet anticorp Transferrin Receptor est conjugé à/à la FITC
    Application
    • 153
    • 139
    • 72
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    • 54
    • 41
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    Flow Cytometry (FACS)
    Specificité
    The antibody MEM-75 reacts with an extracellular epitope of CD71 antigen (transferrin receptor), a 95 kDa type II homodimeric transmembrane glycoprotein expressed on activated B and T lymphocytes, macrophages and erythroid precursors, it is lost on resting blood leukocytes. The antibody MEM-75 does not block binding of transferrin to the receptor.
    Réactivité croisée (Details)
    Human
    Purification
    Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogène
    NALM-6 human pre-B cell line
    Clone
    MEM-75
    Isotype
    IgG1
    Top Product
    Discover our top product TFRC Anticorps primaire
  • Indications d'application
    Flow cytometry: The reagent is designed for analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
    Commentaires

    The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.

    Restrictions
    For Research Use only
  • Reconstitution
    No reconstitution is necessary.
    Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Avoid prolonged exposure to light.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Beck, Balogh, Kis, Izsépi, Cervenak, László, Bíró, Liliom, Mocsár, Vámosi, Füst, Matko: "New cholesterol-specific antibodies remodel HIV-1 target cells' surface and inhibit their in vitro virus production." dans: Journal of lipid research, Vol. 51, Issue 2, pp. 286-96, (2010) (PubMed).

  • Antigène
    Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))
    Autre désignation
    CD71 (TFRC Produits)
    Synonymes
    anticorps Trfr, anticorps LOC100219280, anticorps tfr, anticorps cd71, anticorps tfr1, anticorps trfr, anticorps CD71, anticorps T9, anticorps TFR, anticorps TFR1, anticorps TR, anticorps TRFR, anticorps p90, anticorps 2610028K12Rik, anticorps AI195355, anticorps AI426448, anticorps AU015758, anticorps E430033M20Rik, anticorps Mtvr-1, anticorps Mtvr1, anticorps transferrin receptor, anticorps TFRC, anticorps Tfrc, anticorps tfrc
    Sujet
    Transferrin receptor,CD71 (transferrin receptor) is a type II transmembrane glycoprotein expressed as homodimer in erythroid blood cell line and in activated leukocytes. Upon binding of holotransferrin (complex of transferrin and iron ions), CD71 is internalized by clathrin-mediated endocytosis. Acidification of endosomes by vesicular membrane proton pumps leads to dissociation of iron ions, whereas transferrin (apotransferrin) remains associated with CD71 and recycles to the cell surface, where it is released upon exposure to normal pH . CD71 is also involved in uptake of non-transferrin bound iron.,TfR1, TfR, TR, Trfr, T9, p90, TFRC
    ID gène
    7037
    UniProt
    P02786
    Pathways
    Transition Metal Ion Homeostasis
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