LYN anticorps (AA 8-238)

N° du produit ABIN94427

3+ publications sont disponibles pour ce produit. L’anticorps anti-LYN Monoclonal produit chez le Souris a été validé pour WB, IP et ICC. Il convient pour la détection de LYN dans des échantillons provenant de Humain, Souris et Rat. }

Aperçu rapide pour LYN anticorps (AA 8-238) (ABIN94427)

Antigène: LYN (V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LYN est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Clone: LYN-01

Détail du produit anti-LYN anticorps

Épitope: AA 8-238

Fonction: Anti-LYN Purified

Specificité: The antibody LYN-01 reacts with Lyn (p56/p53), a non-receptor Src-family tyrosine kinase expressed in hematopoietic tissues (intracellular antigen).

Réactivité croisée (Details): Mouse, Human, Rat

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Immunogène: Bacterially expressed recombinant fragment of human Lyn (aa 8 - 238).

Isotype: IgG1

Information d'application

Indications d'application: Western blotting: Recommended dilution: 1-2 μg/mL.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-LYN (ABIN94427)

Queval, Nicolas, Beau: "Role of Src kinases in mobilization of glycosylphosphatidylinositol-anchored decay-accelerating factor by Dr fimbria-positive adhering bacteria." dans: Infection and immunity, Vol. 79, Issue 7, pp. 2519-34, (2011) (PubMed).

Amoui, Dráberová, Tolar, Dráber: "Direct interaction of Syk and Lyn protein tyrosine kinases in rat basophilic leukemia cells activated via type I Fc epsilon receptors." dans: European journal of immunology, Vol. 27, Issue 1, pp. 321-8, (1997) (PubMed).

Dráberová, Amoui, Dráber: "Thy-1-mediated activation of rat mast cells: the role of Thy-1 membrane microdomains." dans: Immunology, Vol. 87, Issue 1, pp. 141-8, (1996) (PubMed).

Détails sur LYN

Antigène: LYN (V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN))

Autre désignation: LYN

Sujet: LYN proto-oncogene, Src family tyrosine kinase,Lyn is a Src-family protein tyrosine kinase that is predominantly expressed in hematopoietic cells. It is associated with a number of cell surface receptors including the B cell antigen receptor (BCR) and Fc receptors. Upon their triggering, Lyn phosphorylates subunits of these receptors in a cholesterol-dependent manner, utilizing the plasma membrane lipid raft system. The phosphorylated intracellular domains of the receptors are accessible for cytoplasmic Syk tyrosine kinase, which is activated by Lyn-mediated phosphorylation and which transduces the signal to downstream adaptors. Lyn is abnormally distributed in acute myeloid leukemia cells and seems to be a novel pharmacologic target of this disease.,JTK8, p56Lyn, p53Lyn

ID gène: 4067

UniProt: P07948

Pathways: Fc-epsilon Receptor Signaling Pathway, Hormone Transport, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling, Integrin Complex, BCR Signaling