ADAM9 anticorps (Extracellular Domain)

N° du produit ABIN950269

Cet anticorps Rat Monoclonal détecte spécifiquement ADAM9 dans WB. Il présente une réactivité envers Souris.

Aperçu rapide pour ADAM9 anticorps (Extracellular Domain) (ABIN950269)

Antigène: ADAM9 (ADAM Metallopeptidase Domain 9 (ADAM9))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp ADAM9 est non-conjugé

Application: Western Blotting (WB)

Clone: 7D10

Détail du produit anti-ADAM9 anticorps

Épitope: Extracellular Domain

Purification: Protein A/G Affinity Chromatography

Immunogène: Purified Recombinant ADAM9 extracellular domain.

Isotype: IgG2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore with 200 μL sterile PBS and the final concentration is 500 μg/mL.

Buffer: 0.2 μm filtered PBS solution, None

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Prior to reconstitution store at -70 °C. Following reconstitution store the antibody (in aliquots) at -20 °C for 6 months.

Date de péremption: 6 months

Détails sur ADAM9

Antigène: ADAM9 (ADAM Metallopeptidase Domain 9 (ADAM9))

Autre désignation: ADAM9 / MDC9

Sujet: ADAM9, also known as MDC9 or meltrin γ, is a member of the ADAM family that contains a disintegrin and metalloprotease-like domain. Like other membrane-anchored ADAMs, ADAM9 consists of a pro domain with a cysteine switch and furin cleavage sequence, a catalytic domain with the zinc-binding site and Metturn expected for reprolysins, a disintegrin like domain, a cysteine-rich domain, an EGF-like domain, a transmembrane domain, and the cytoplasmic domain. ADAM9 is able to cleave peptides corresponding to cleavage sites of tumor necrosis factorα (TNFα), the p75 TNF receptor, the β-amyloid protein precursor, and the c-kit ligand1, implying that it may participate in shedding of these membrane proteins. In fact, ADAM9 has been shown to shed membrane-anchored heparin-binding EGF-like growth factor. In addition, it also cleaves oxidized insulin B-chain and fibronectin. Besides its catalytic activity, ADAM9 functions as an adhesion molelcule through binding of its disintegrin domain to integrins such as αvβ5 and α6β1. The cytoplasmic domain of ADAM9 interacts with Src homology 3 (SH3)containing proteins and protein kinase C, and may mediate different signaling pathways. ADAM9 is widely expressed in tissues.Synonyms: Cellular disintegrin-related protein, Disintegrin and metalloproteinase domain-containing protein 9, KIAA0021, MCMP, MLTNG, Meltrin gamma, Metalloprotease/disintegrin/cysteine-rich protein 9, Myeloma cell metalloproteinase

ID gène: 10090

UniProt: Q61072

Pathways: Cellular Response to Molecule of Bacterial Origin, SARS-CoV-2 Protein Interactome