Amyloid Fibrils anticorps

N° du produit ABIN950406

Détail du produit

Antigène: Amyloid Fibrils

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), Dot Blot (DB), Immunoprecipitation (IP), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Protein A Chromatography

Immunogène: Fibrils prepared from Human Abeta42 peptide.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS, 0.09 % Sodium Azide, 50 % Glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Référence

Nakajima, Nishitsuji, Kawashima, Kuwabara, Mikawa, Uchimura, Akaji, Kashiwada, Kobayashi, Saito, Sakashita: "The polyphenol (-)-epigallocatechin-3-gallate prevents apoA-IIowa amyloidosis in vitro and protects human embryonic kidney 293 cells against amyloid cytotoxicity." dans: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, Vol. 23, Issue 1, pp. 17-25, (2016) (PubMed).

Jackson, Onos, Pepper, Graham, Akeson, Byers, Reinholdt, Frankel, Howell: "DBA/2J genetic background exacerbates spontaneous lethal seizures but lessens amyloid deposition in a mouse model of Alzheimer's disease." dans: PLoS ONE, Vol. 10, Issue 5, pp. e0125897, (2016) (PubMed).

Tang, Dai, He, Doty, Shultz, Sampson, Dai: "MEK guards proteome stability and inhibits tumor-suppressive amyloidogenesis via HSF1." dans: Cell, Vol. 160, Issue 4, pp. 729-44, (2015) (PubMed).

Détail du antigène

Antigène: Amyloid Fibrils

Sujet: Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres (1, 2). These include the amyloid-β peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer's symptomology, the deposition of α-synuclein in the Lewy bodies of Parkinson's disease, and accumulation of polyglutamine-containing aggregates in Huntington's disease (2, 3).Synonyms: Fibrils, OC