TEK anticorps (AA 23-737)

N° du produit ABIN951225

L’anticorps Lapin Polyclonal anti-TEK a été validé pour WB. Il convient pour détecter TEK dans des échantillons de Souris.

Aperçu rapide pour TEK anticorps (AA 23-737) (ABIN951225)

Antigène: TEK (TEK Tyrosine Kinase, Endothelial (TEK))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TEK est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-TEK anticorps

Épitope: AA 23-737

Specificité: Recognizes TIE-2 (CD202b/TEK)

Réactivité croisée (Details): Species reactivity (tested):Mouse, Human (Weak).

Purification: Protein A Chromatography

Immunogène: Highly pure (>95%) recombinant Mouse soluble TIE-2 (Ala23-Ala737) derived from Insect cells.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: PBS, pH 7.2

Stock: 4 °C/-20 °C

Stockage commentaire: The lyophilized antibody is stable at RT for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 °C. Frozen aliquots are stable for at least 6 months when stored at -20 °C. Avoid repeated freeze-thaw cycles!

Date de péremption: 6 months

Détails sur TEK

Antigène: TEK (TEK Tyrosine Kinase, Endothelial (TEK))

Autre désignation: CD202b / TEK

Sujet: Recombinant Mouse soluble TIE-1 was fused with a 6x His-tag at the C-terminus. The soluble receptor protein consists of the full extracellular domain (Ser22-Ala748). Mouse sTIE-1 monomer has a calculated molecular mass of approximately 79,8 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 95 kDa protein in SDS-PAGE under reducing conditions. TIE-1 (tyrosine kinase with Ig and EGF homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis.Synonyms: Angiopoietin-1 receptor, TIE-2, TIE2, Tunica interna endothelial cell kinase, Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2, p140 TEK

ID gène: 7010

NCBI Accession: NP_000450

Pathways: Signalisation RTK, Growth Factor Binding