F12 anticorps (N-Term)

N° du produit ABIN951608

Détail du produit anti-F12 anticorps

Antigène: F12 (Coagulation Factor XII (F12))

Épitope: AA 13-43, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp F12 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody recognizes Human Coagulation factor XII (F12) (N-term).

Purification: Affinity Chromatography on Protein A

Immunogène: KLH conjugated synthetic peptide between 13~43 amino acids from the N-terminal region of human F12

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur F12

Antigène: F12 (Coagulation Factor XII (F12))

Abstract: F12 Produits

Synonymes: anticorps HAE3, anticorps HAEX, anticorps HAF, anticorps FXII, anticorps coagulation factor XII, anticorps coagulation factor XII (Hageman factor), anticorps F12

Sujet: This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI.Synonyms: HAF, Hageman factor

Poids moléculaire: 67818 Da

ID gène: 2161

NCBI Accession: NP_000496

Pathways: Système du Complément