COX10 anticorps (C-Term)

N° du produit ABIN951674

L’anticorps Lapin Polyclonal anti-COX10 a été validé pour WB, FACS, IHC (p) et EIA. Il convient pour détecter COX10 dans des échantillons de Humain.

Aperçu rapide pour COX10 anticorps (C-Term) (ABIN951674)

Antigène: COX10 (Cytochrome C Oxidase Assembly Homolog 10 (COX10))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp COX10 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-COX10 anticorps

Épitope: AA 386-414, C-Term

Specificité: This antibody reacts to COX10.

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography on Protein A

Immunogène: KLH conjugated synthetic peptide between 386-414 amino acids from the C-terminal region of human COX1

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur COX10

Antigène: COX10 (Cytochrome C Oxidase Assembly Homolog 10 (COX10))

Autre désignation: COX10

Sujet: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion.Synonyms: COX-10, Heme O synthase, mitochondrial Protoheme IX farnesyltransferase

Poids moléculaire: 48910 Da

ID gène: 1352

NCBI Accession: NP_001294