KDM3B anticorps (Middle Region)

N° du produit ABIN952970

L’anticorps Lapin Polyclonal anti-KDM3B a été validé pour WB, FACS et EIA. Il convient pour détecter KDM3B dans des échantillons de Humain.

Aperçu rapide pour KDM3B anticorps (Middle Region) (ABIN952970)

Antigène: KDM3B (Lysine (K)-Specific Demethylase 3B (KDM3B))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KDM3B est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Détail du produit anti-KDM3B anticorps

Épitope: AA 876-905, Middle Region

Specificité: This antibody recognizes Human JMJD1B / KDM3B (Center).

Purification: Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS

Immunogène: KLH conjugated synthetic peptide between 876-905 amino acids from the Central region of human JHDM2b Genename: KDM3B

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur KDM3B

Antigène: KDM3B (Lysine (K)-Specific Demethylase 3B (KDM3B))

Autre désignation: JMJD1B / KDM3B

Sujet: Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.Synonyms: 5qNCA, C5orf7, JHDM2B, JmjC domain-containing histone demethylation protein 2B, Jumonji domain-containing protein 1B, KIAA1082, Lysine-specific demethylase 3B, Nuclear protein 5qNCA

Poids moléculaire: 84kd

ID gène: 51780

NCBI Accession: NP_057688

Pathways: L'effet Warburg