MBP anticorps

N° du produit ABIN953563

Cet anticorps Poulet Polyclonal détecte spécifiquement MBP dans WB et IF. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour MBP anticorps (ABIN953563)

Antigène: MBP (Myelin Basic Protein (MBP))

Reactivité: Humain, Souris, Rat

Hôte: Poulet

Clonalité: Polyclonal

Conjugué: Cet anticorp MBP est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-MBP anticorps

Specificité: Specific for the ~18k & 22k myelin basic protein in Western blots of Rat brain homogenate.

Réactivité croisée (Details): Species reactivity (tested):Human, Bovine, Mouse and Rat.

Purification: Ig Fraction

Immunogène: Three peptide sequences conserved in higher vertebrate MBP proteins.

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at -20 °C.

Détails sur MBP

Antigène: MBP (Myelin Basic Protein (MBP))

Autre désignation: Myelin Basic Protein

Sujet: Myelin Basic Protein (MBP) is one of the major proteins of the myelin sheath surrounding axons in the nervous system. Since it is of relatively low molecular weight and high abundance the protein sequence was determined from purified protein over 30 years ago (Eylar et al., 1971). The protein is made by oligodendrocytes in the central nervous system, so antibodies to MBP are good markers of this cell type. However, transcripts from the same gene are also expressed in certain hematopoetic lineage cells (Marty et al., 2002). In the central nervous system there are there different forms of the protein made by alternate transcription from a single gene, which have molecular weights of 21.5, 18.5, and 17.2 kDa. Since the two lower molecular weight forms are very close in molecular size, MBP antibodies typically show two bands on Western blots, one at about 22 kDa and another at about 18 kDa.Synonyms: MBP, Myelin membrane encephalitogenic protein

ID gène: 4155

NCBI Accession: NP_001020252

UniProt: P02686