SAR1B anticorps (Middle Region)

N° du produit ABIN954670

Cet anticorps Lapin Polyclonal détecte spécifiquement SAR1B dans WB, IHC (p) et EIA. Il présente une réactivité envers Humain.

Aperçu rapide pour SAR1B anticorps (Middle Region) (ABIN954670)

Antigène: SAR1B (SAR1 Homolog B (SAR1B))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SAR1B est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-SAR1B anticorps

Épitope: AA 96-124, Middle Region

Specificité: Recognizes SAR1B (Center).

Purification: Protein A column followed by peptide Affinity purification

Immunogène: KLH conjugated synthetic peptide between 96-124 amino acids from the Central region of Human SAR1B Genename: SAR1B

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur SAR1B

Antigène: SAR1B (SAR1 Homolog B (SAR1B))

Autre désignation: SAR1B

Sujet: SAR1B belongs to the small GTPase superfamily, SAR1 family. It is involved in transport from the endoplasmic reticulum to the Golgi apparatus and is activated by the guanine nucleotide exchange factor PREB. SAR1B is involved in the selection of the protein cargo and the assembly of the COPII coat complex. Defects in SAR1B are the cause of chylomicron retention disease (CMRD). CMRD is an autosomal recessive disorder of severe fat malabsorption associated with failure to thrive in infancy. The conditions are characterized by deficiency of fat-soluble vitamins, low blood cholesterol levels, and a selective absence of chylomicrons from blood. Affected individuals accumulate chylomicron-like particles in membrane-bound compartments of enterocytes, which contain large cytosolic lipid droplets. Cellular localization: Endoplasmic reticulum membrane, Peripheral membrane protein. Golgi apparatus, Golgi stack membrane, Peripheral membrane protein. Associated with the endoplasmic reticulum and Golgi stacks, in particular in the juxta-nuclear Golgi region.Synonyms: GTBPB, GTP-binding protein SAR1b, SAR1B, SARA2, SARB

ID gène: 51128

NCBI Accession: NP_001028675

Pathways: Lipid Metabolism