Topoisomerase II alpha anticorps (C-Term)

N° du produit ABIN955291

Cet anticorps Lapin Polyclonal détecte spécifiquement Topoisomerase II alpha dans WB et EIA. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Topoisomerase II alpha anticorps (C-Term) (ABIN955291)

Antigène: Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Topoisomerase II alpha est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-Topoisomerase II alpha anticorps

Épitope: AA 1433-1461, C-Term

Specificité: This antibody detects TOP2A (C-term).

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Protein A column followed by peptide affinity purification

Immunogène: KLH conjugated synthetic peptide between 1433-1461 amino acids from the C-terminal region of human TOP2A/Topo?.

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.

Détails sur Topoisomerase II alpha

Antigène: Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))

Autre désignation: TOP2A

Sujet: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.Synonyms: DNA topoisomerase 2-alpha, DNA topoisomerase II alpha isozyme, TOP2, Top-2

ID gène: 7153

NCBI Accession: NP_001058

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases