CASZ1 anticorps (Internal Region)

N° du produit ABIN964598

Détail du produit anti-CASZ1 anticorps

Antigène: CASZ1 (Castor Zinc Finger 1 (CASZ1))

Épitope: Internal Region

Reactivité: Humain, Souris, Chimpanzé, Drosophila melanogaster, Macaque

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CASZ1 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: This affinity purified antibody is directed against human CASZ1 protein. The product was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest reactivity with CASZ1 proteins from human, mouse, Drosophila, chimpanzee, and macaque based on a 100% homology. Partial reactivity is expected with horse and dog CASZ1 based on a 92% homology with the immunizing sequence. Cross-reactivity with CASZ1 from other sources has not been determined.

Réactivité croisée: Souris, Mouche des fruits (Drosophila melanogaster), Chimpanzé, Macaque

Attributs du produit: This antibody is designed, produced, and validated as part of a collaboration with the National Cancer Institute (NCI) and is suitable for Cancer, Immunology and Nuclear Signaling research. The human castor zinc finger 1 gene (CASZ1) regulates the production of the castor transcription factor, having increased expression when cells of neural and mesenchymal origin are induced to differentiation. CASZ1 is expressed in a number of human tumors and it localizes to a genomic region frequently lost in tumors of neuroectodermal origin. The CASZ1 gene generates 2 mRNA isoforms hCASZ5 and hCASZ11 that could encode proteins containing 5 or 11 zinc finger motifs, respectively. The proteins may be especially labile. Expect a band at 125 kDa for hCASZ5 and 190 kDa for hCASZ11 in fresh lysates.

Purification: affinity purified

Stérilité: Sterile filtered

Immunogène: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region of Human Casz1 protein.
Immunogen Type: Peptide

Isotype: IgG

Information d'application

Indications d'application: This antibody has been tested for use in ELISA and western blotting. This antiserum detects endogenous CASZ1 proteins, both the hCASZ5 and hCASZ11 isoforms. Expect a band approximately 125 kDa for hCASZ5 and 190 kDa for hCASZ11 in size corresponding CASZ1 by western blotting in the appropriate cell lysate or extract. Specific conditions for reactivity should be optimized by the end user.

Commentaires:

Gene Name: CASZ1

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.09 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.

Stock: 4 °C/-20 °C

Stockage commentaire: Store vial at 4 ° C prior to restoration. For extended storage aliquot contents and freeze at -24 ° C or below. This product is stable for several weeks at 4 ° C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.

Date de péremption: 12 months

Références pour anticorps anti-CASZ1 (ABIN964598)

Lunde, Okaty, Dymecki, Glover: "Molecular Profiling Defines Evolutionarily Conserved Transcription Factor Signatures of Major Vestibulospinal Neuron Groups." dans: eNeuro, Vol. 6, Issue 1, (2019) (PubMed).

Zhang, Bonasio, Strino, Kluger, Holloway, Modzelewski, Cohen, Reinberg: "SFMBT1 functions with LSD1 to regulate expression of canonical histone genes and chromatin-related factors." dans: Genes & development, Vol. 27, Issue 7, pp. 749-66, (2013) (PubMed).

Détails sur CASZ1

Antigène: CASZ1 (Castor Zinc Finger 1 (CASZ1))

Autre désignation: CASZ1 (CASZ1 Produits)

Synonymes: anticorps sb:eu580, anticorps wu:fk85f10, anticorps csta, anticorps castor, anticorps CAS11, anticorps CST, anticorps SRG, anticorps ZNF693, anticorps dJ734G22.1, anticorps 2410019P08Rik, anticorps AV096627, anticorps BC040081, anticorps Cst, anticorps D4Ertd432e, anticorps RGD1563533, anticorps castor zinc finger 1, anticorps castor zinc finger 1 L homeolog, anticorps CASZ1, anticorps casz1, anticorps casz1.L, anticorps Casz1

Sujet: This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. The human castor zinc finger 1 gene (CASZ1) regulates the production of the castor transcription factor, having increased expression when cells of neural and mesenchymal origin are induced to differentiation. CASZ1 is expressed in a number of human tumors and it localizes to a genomic region frequently lost in tumors of neuroectodermal origin. The CASZ1 gene generates 2 mRNA isoforms hCASZ5 and hCASZ11 that could encode proteins containing 5 or 11 zinc finger motifs, respectively. The proteins may be especially labile. Expect a band at 125 kDa for hCASZ5 and 190 kDa for hCASZ11 in fresh lysates.
Synonyms: CASZ1, Zinc finger protein castor homolog 1, Castor-related protein, Zinc finger protein 693

ID gène: 54897, 145207289

UniProt: Q86V15