IL-13 anticorps

N° du produit ABIN964711

N° du produit (Fournisseur): 200-401-b55

Cet anticorps Lapin Polyclonal détecte spécifiquement IL-13 dans WB et ELISA. Il présente une réactivité envers Porc, Boeuf (Vache) et Mouton.

Aperçu rapide pour IL-13 anticorps (ABIN964711)

Antigène: IL-13 (IL13) (Interleukin 13 (IL13))

Reactivité: Porc, Boeuf (Vache), Mouton

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL-13 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-IL-13 anticorps

N° du produit (Fournisseur): 200-401-b55

Fournisseur: Rockland

Fonction: IL13 Antibody

Réactivité croisée (Details): This antibody is specific for swine IL-13 protein.

Attributs du produit: Synonyms: rabbit anti-Interleukin-13 antibody, rabbit anti-IL-13 antibody, IL13, Interleukin13, IL 13, Interleukin 13

Purification: This product was Protein-A purified from monospecific antiserum by chromatography.

Immunogène:

Immunogen: This protein-A purified antibody was prepared from whole rabbit serum produced by repeated immunizations with full length recombinant protein raised in yeast, corresponding to mature swine IL-13 protein.

Immunogen Type: Recombinant Protein

Isotype: IgG

Information d'application

Indications d'application:

Application Note: IL-13 antibody has been tested for use in ELISA and western blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 13.2 kDa in size corresponding to swine IL-13 protein by western blotting in the appropriate cell lysate or extract.

Western Blot Dilution: 1.5 to 2 μg/mL

ELISA Dilution: 1:11,000

Other: User Optimized

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution:

Reconstitution Volume: 100 μL

Reconstitution Buffer: Restore with deionized water (or equivalent)

Concentration: 1.0 mg/mL

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: None

Preservative: 0.01 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store vial at 4° C prior to restoration. For extended storage aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Date de péremption: 12 months

Détails sur IL-13

Antigène: IL-13 (IL13) (Interleukin 13 (IL13))

Autre désignation: IL13

Sujet: Background: Interleukin 13 (IL-13), of the IL-4 superfamily, is a cytokine secreted by many cell types, but especially T helper type 2 (Th2) cells, that is an important mediator of allergic inflammation and disease. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rα) and at least one IL-13-specific binding chain. Most of the biological effects of IL-13, like those of IL-4, are linked to a single transcription factor, STAT6. In humans, IL-13 can induce immunoglobulin E (IgE) secretion from activated B cells. In mice, deletion of IL-13 does not markedly affect either Th2 cell development or antigen-specific IgE responses induced by potent allergens. Deletion of IL-4 abrogates these responses. IL-13 acts as a molecular bridge linking allergic inflammatory cells to the non-immune cells in contact with them, thus altering physiological function. Although IL-13 is associated primarily with the induction of airway disease, including airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion, it also induces airway matrix metalloproteinases as part of a mechanism that protects against excessive allergic inflammation that predisposes to asphyxiation. Anti-IL-13 antibody is ideal for investigators involved in Cancer and Immunology research.

ID gène: 396721, 189176151

UniProt: B3GDZ5

Pathways: Signalistation JAK/STAT, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport