Androgen Receptor anticorps (AA 689-919)

N° du produit ABIN965588

L’anticorps Souris Monoclonal anti-Androgen Receptor a été validé pour WB et ELISA. Il convient pour détecter Androgen Receptor dans des échantillons de Humain. Il y a 2+ publications disponibles.

Aperçu rapide pour Androgen Receptor anticorps (AA 689-919) (ABIN965588)

Antigène: Androgen Receptor (AR)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Androgen Receptor est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 1A9D12

Détail du produit anti-Androgen Receptor anticorps

Épitope: AA 689-919

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of AR (aa689-919) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Format: Liquid

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Références pour anticorps anti-Androgen Receptor (ABIN965588)

Zong, Chi, Wang, Yang, Zhang, Chen, Jiang, Li, Hong, Wang, Yun, Gu: "Cyclin D3/CDK11p58 complex is involved in the repression of androgen receptor." dans: Molecular and cellular biology, Vol. 27, Issue 20, pp. 7125-42, (2007) (PubMed).

Lindström, Wiklund, Adami, Bälter, Adolfsson, Grönberg: "Germ-line genetic variation in the key androgen-regulating genes androgen receptor, cytochrome P450, and steroid-5-alpha-reductase type 2 is important for prostate cancer development." dans: Cancer research, Vol. 66, Issue 22, pp. 11077-83, (2006) (PubMed).

Détails sur Androgen Receptor

Antigène: Androgen Receptor (AR)

Autre désignation: AR

Sujet: AR: androgen receptor. The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.
Synonyms: KD, AIS, TFM, DHTR, SBMA

ID gène: 367

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding