SRRT anticorps (C-Term)

N° du produit ABIN965596

Cet anticorps Lapin Polyclonal détecte spécifiquement SRRT dans IHC. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour SRRT anticorps (C-Term) (ABIN965596)

Antigène: SRRT (Serrate RNA Effector Molecule Homolog (SRRT))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SRRT est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-SRRT anticorps

Épitope: C-Term

Purification: Purified by antigen-specific affinity chromatography.

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human ARS2 (Arsenite-resistance protein 2)

Information d'application

Indications d'application: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur SRRT

Antigène: SRRT (Serrate RNA Effector Molecule Homolog (SRRT))

Autre désignation: ARS2

Sujet: ARS2(Arsenite-resistance protein 2) confers arsenite resistance The protein belongs to the ARS2 family. Arsenic is a human carcinogen whose mechanism of action is unknown. The arsenite acts as a comutagen by interfering with DNA repair. Two genes, ASR1(Arsenite-resistance protein 1) and ASR2(Arsenite-resistance protein 2), confer arsenite resistance to arsenite-sensitive cells. ASR1 shows almost complete homology with the rat fau gene, a tumor suppressor gene which contains a ubiquitinlike region fused to S30 ribosomal protein. Arsenite inhibits ubiquitin-dependent proteolysis. The tumor suppressor fau gene product or some other aspect of the ubiquitin system may be a target for arsenic toxicity and that disruption of the ubiquitin system may contribute to the genotoxicity and carcinogenicity of arsenite.

Pathways: Signalisation Notch, Stem Cell Maintenance