ChT anticorps (C-Term)

N° du produit ABIN965895

Détail du produit anti-ChT anticorps

Antigène: ChT (High Affinity Choline Transporter (ChT))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ChT est non-conjugé

Application: Immunohistochemistry (IHC)

Purification: Purified by antigen-specific affinity chromatography.

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human choline transporter

Information d'application

Indications d'application: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-ChT (ABIN965895)

Apparsundaram, Ferguson, George, Blakely: "Molecular cloning of a human, hemicholinium-3-sensitive choline transporter." dans: Biochemical and biophysical research communications, Vol. 276, Issue 3, pp. 862-7, (2000) (PubMed).

Détails sur ChT

Antigène: ChT (High Affinity Choline Transporter (ChT))

Autre désignation: CHT1 (ChT Produits)

Synonymes: anticorps CHT, anticorps CHT1, anticorps HMN7A, anticorps hCHT, anticorps Cht1, anticorps solute carrier family 5 member 7, anticorps solute carrier family 5 (choline transporter), member 7, anticorps SLC5A7, anticorps Slc5a7

Sujet: The choline transporter is a hemicholinium-3-sensitive phosphorylated transmembrane protein, the protein regulates high-affinity choline uptake, and plays the roles in disease states. CHT1(High-affinity choline transporter 1) imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. CHT1 is sodium ionand chloride ion-dependent. CHT1 is expressed in putamen, spinal cord and medulla and is specific for cholinergic neurons. CHT1 is specifically inhibited by nanomolar concentrations of hemicholinium 3. CHT1 belongs to the sodium: solute symporter (SSF) (TC 2.A.21) family.