KRT17 anticorps

N° du produit ABIN965900

L’anticorps Souris Monoclonal anti-KRT17 a été validé pour WB, IHC et ELISA. Il convient pour détecter KRT17 dans des échantillons de Humain. Il y a 2+ publications disponibles.

Aperçu rapide pour KRT17 anticorps (ABIN965900)

Antigène: KRT17 (Keratin 17 (KRT17))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp KRT17 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: 3B12

Détail du produit anti-KRT17 anticorps

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of CK17 expressed in E. Coli.

Isotype: IgG2b

Information d'application

Indications d'application: Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Format: Liquid

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Références pour anticorps anti-KRT17 (ABIN965900)

van de Rijn, Perou, Tibshirani, Haas, Kallioniemi, Kononen, Torhorst, Sauter, Zuber, Köchli, Mross, Dieterich, Seitz, Ross, Botstein, Brown: "Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome." dans: The American journal of pathology, Vol. 161, Issue 6, pp. 1991-6, (2002) (PubMed).

Leigh, Navsaria, Purkis, McKay, Bowden, Riddle: "Keratins (K16 and K17) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro." dans: The British journal of dermatology, Vol. 133, Issue 4, pp. 501-11, (1995) (PubMed).

Détails sur KRT17

Antigène: KRT17 (Keratin 17 (KRT17))

Autre désignation: CK17

Sujet: CK17, also known as KRT17, it is the type I intermediate filament chain keratin 17. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial stem cells. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair.
Synonyms: PC, K17, PC2, PCHC1, KRT17

Poids moléculaire: 49kDa

ID gène: 3872