DDX58 anticorps (N-Term)

N° du produit ABIN965985

Cité dans 5 publications. Cet anticorps anti-DDX58 Polyclonal Lapin (ABIN965985) détecte spécifiquement DDX58 dans IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour DDX58 anticorps (N-Term) (ABIN965985)

Antigène: DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DDX58 est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-DDX58 anticorps

Épitope: N-Term

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human DDX58 (Probable ATP-dependent RNA helicase DDX58)

Information d'application

Restrictions: For Research Use only

Stockage

Stock: 4 °C

Références pour anticorps anti-DDX58 (ABIN965985)

Seth, Sun, Ea, Chen: "Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3." dans: Cell, Vol. 122, Issue 5, pp. 669-82, (2005) (PubMed).

Huang, Liu, Xu, Chen, Zhai, Shu: "SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways." dans: The EMBO journal, Vol. 24, Issue 23, pp. 4018-28, (2005) (PubMed).

Sumpter, Loo, Foy, Li, Yoneyama, Fujita, Lemon, Gale: "Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I." dans: Journal of virology, Vol. 79, Issue 5, pp. 2689-99, (2005) (PubMed).

Cui, Imaizumi, Yoshida, Borden, Satoh: "Retinoic acid-inducible gene-I is induced by interferon-gamma and regulates the expression of interferon-gamma stimulated gene 15 in MCF-7 cells." dans: Biochemistry and cell biology = Biochimie et biologie cellulaire, Vol. 82, Issue 3, pp. 401-5, (2004) (PubMed).

Imaizumi, Aratani, Nakajima, Carlson, Matsumiya, Tanji, Ookawa, Yoshida, Tsuchida, McIntyre, Prescott, Zimmerman, Satoh: "Retinoic acid-inducible gene-I is induced in endothelial cells by LPS and regulates expression of COX-2." dans: Biochemical and biophysical research communications, Vol. 292, Issue 1, pp. 274-9, (2002) (PubMed).

Détails sur DDX58

Antigène: DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))

Autre désignation: DDX58

Sujet: DDX58 (Probable ATP-dependent RNA helicase DDX58) is involved in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). Essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza viruses, Japanese encephalitis virus and HCV. DDX58 (Probable ATP-dependent RNA helicase DDX58) is maintained as a monomer in an autoinhibited state. Upon viral dsRNA binding and conformation shift, homomultimerizes and interacts with MAVS. Interacts with DHX58/LGP2, IKBKE, TBK1 and TMEM173/STING. DDX58 (Probable ATP-dependent RNA helicase DDX58) is present in vascular smooth cells at protein level. DDX58 belongs to the helicase family and contains 2 CARD domains, 1 helicase ATP-binding domain and 1 helicase C-terminal domain.
Synonyms: DEAD-box protein 58, RIG-1 (Retinoic acid-inducible gene 1 protein)

Pathways: Activation of Innate immune Response, Hepatitis C