FANCD2 anticorps (Isoform B)

N° du produit ABIN966127

Cet anticorps Lapin Polyclonal détecte spécifiquement FANCD2 dans IHC. Il présente une réactivité envers Humain et Souris et a été mentionné dans 4+ publications.

Aperçu rapide pour FANCD2 anticorps (Isoform B) (ABIN966127)

Antigène: FANCD2 (Fanconi Anemia, Complementation Group D2 (FANCD2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FANCD2 est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-FANCD2 anticorps

Épitope: Isoform B

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human FANCD2 (Fanconi anemia complementation group D2 isoform b)

Information d'application

Restrictions: For Research Use only

Stockage

Stock: 4 °C

Références pour anticorps anti-FANCD2 (ABIN966127)

Kweekel, Antonini, Nortier, Punt, Gelderblom, Guchelaar: "Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array." dans: British journal of cancer, Vol. 101, Issue 2, pp. 357-62, (2009) (PubMed).

Singh, Bakker, Agarwal, Jansen, Grassman, Godthelp, Ali, Du, Rooimans, Fan, Wahengbam, Steltenpool, Andreassen, Williams, Joenje, de Winter, Meetei: "Impaired FANCD2 monoubiquitination and hypersensitivity to camptothecin uniquely characterize Fanconi anemia complementation group M." dans: Blood, Vol. 114, Issue 1, pp. 174-80, (2009) (PubMed).

Kuhnert, Kachnic, Li, Purschke, Gheorghiu, Lee, Held, Willers: "FANCD2-deficient human fibroblasts are hypersensitive to ionising radiation at oxygen concentrations of 0% and 3% but not under normoxic conditions." dans: International journal of radiation biology, Vol. 85, Issue 6, pp. 523-31, (2009) (PubMed).

Chan, Palmai-Pallag, Ying, Hickson: "Replication stress induces sister-chromatid bridging at fragile site loci in mitosis." dans: Nature cell biology, Vol. 11, Issue 6, pp. 753-60, (2009) (PubMed).

Détails sur FANCD2

Antigène: FANCD2 (Fanconi Anemia, Complementation Group D2 (FANCD2))

Autre désignation: FANCD2

Sujet: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity, they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homologydirected DNA repair. Alternative splicing results in two transcript variants encoding different isoforms.

Pathways: Réparation de l'ADN