MLL/KMT2A anticorps (N-Term)

N° du produit ABIN966301

Cet anticorps Lapin Polyclonal détecte spécifiquement MLL/KMT2A dans IHC. Il présente une réactivité envers Humain et a été mentionné dans 7+ publications.

Aperçu rapide pour MLL/KMT2A anticorps (N-Term) (ABIN966301)

Antigène: MLL/KMT2A (MLL) (Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MLL/KMT2A est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-MLL/KMT2A anticorps

Épitope: N-Term

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to near N-terminal residues of human HRX (Histone-lysine N-methyltransferase HRX)

Information d'application

Restrictions: For Research Use only

Stockage

Stock: 4 °C

Références pour anticorps anti-MLL/KMT2A (ABIN966301)

Nilson, Löchner, Siegler, Greil, Beck, Fey, Marschalek: "Exon/intron structure of the human ALL-1 (MLL) gene involved in translocations to chromosomal region 11q23 and acute leukaemias." dans: British journal of haematology, Vol. 93, Issue 4, pp. 966-72, (1996) (PubMed).

Mbangkollo, Burnett, McCabe, Thirman, Gill, Yu, Rowley, Diaz: "The human MLL gene: nucleotide sequence, homology to the Drosophila trx zinc-finger domain, and alternative splicing." dans: DNA and cell biology, Vol. 14, Issue 6, pp. 475-83, (1995) (PubMed).

Gu, Alder, Nakamura, Schichman, Prasad, Canaani, Saito, Croce, Canaani: "Sequence analysis of the breakpoint cluster region in the ALL-1 gene involved in acute leukemia." dans: Cancer research, Vol. 54, Issue 9, pp. 2327-30, (1994) (PubMed).

Yamamoto, Seto, Komatsu, Iida, Akao, Kojima, Kodera, Nakazawa, Ariyoshi, Takahashi: "Two distinct portions of LTG19/ENL at 19p13 are involved in t(11;19) leukemia." dans: Oncogene, Vol. 8, Issue 10, pp. 2617-25, (1993) (PubMed).

Tkachuk, Kohler, Cleary: "Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias." dans: Cell, Vol. 71, Issue 4, pp. 691-700, (1992) (PubMed).

Gu, Nakamura, Alder, Prasad, Canaani, Cimino, Croce, Canaani: "The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene." dans: Cell, Vol. 71, Issue 4, pp. 701-8, (1992) (PubMed).

Howell, Rao: "Cloning a replication function from the streptomycete bacteriophage FP43." dans: Gene, Vol. 113, Issue 1, pp. 113-7, (1992) (PubMed).

Détails sur MLL/KMT2A

Antigène: MLL/KMT2A (MLL) (Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))

Autre désignation: HRX

Sujet: HRX (Histone-lysine N-methyltransferase HRX) functions as histone methyltransferase. HRX methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. HRX promotes PPP1R15A-induced apoptosis. HRX interacts with SBF1 and PPP1R15A. HRX is a component of the MLL complex, at least composed of MLL, ASH2L, RBBP5, DPY30, WDR5, MEN1,HCFC1 and HCFC2. Chromosomal aberrations involving MLL are a cause of acute leukemias. A chromosomal aberration involving MLL may be a cause of chronic neutrophilic leukemia. HRX belongs to the histone-lysine methyltransferase family and TRX/MLL subfamily.
Synonyms: ALL1, CXXC7(CXXC-type zinc finger protein 7), HTRX, KMT2A, TRX1, MLL, Zinc finger protein HRX, Trithorax-like protein, Lysine N-methyltransferase 2A

Pathways: L'effet Warburg