L3MBTL1 anticorps (N-Term)

N° du produit ABIN966472

Cet anticorps Lapin Polyclonal détecte spécifiquement L3MBTL1 dans IHC. Il présente une réactivité envers Humain et a été mentionné dans 3+ publications.

Aperçu rapide pour L3MBTL1 anticorps (N-Term) (ABIN966472)

Antigène: L3MBTL1 (L(3)mbt-Like 1 (L3MBTL1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp L3MBTL1 est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-L3MBTL1 anticorps

Épitope: N-Term

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human L3MBTL(Lethal(3)malignant brain tumor-like protein )

Information d'application

Restrictions: For Research Use only

Stockage

Stock: 4 °C

Références pour anticorps anti-L3MBTL1 (ABIN966472)

Boccuni, MacGrogan, Scandura, Nimer: "The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6)." dans: The Journal of biological chemistry, Vol. 278, Issue 17, pp. 15412-20, (2003) (PubMed).

Wang, Tereshko, Boccuni, MacGrogan, Nimer, Patel: "Malignant brain tumor repeats: a three-leaved propeller architecture with ligand/peptide binding pockets." dans: Structure (London, England : 1993), Vol. 11, Issue 7, pp. 775-89, (2003) (PubMed).

Koga, Matsui, Hirota, Takebayashi, Okumura, Saya: "A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes." dans: Oncogene, Vol. 18, Issue 26, pp. 3799-809, (1999) (PubMed).

Détails sur L3MBTL1

Antigène: L3MBTL1 (L(3)mbt-Like 1 (L3MBTL1))

Autre désignation: L3MBTL

Sujet: L3MBTL(Lethal(3)malignant brain tumor-like protein ) is polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. L3MBTL participates in the ETV6-mediated repression. L3MBTL probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis. L3MBTL interacts with ETV6 and is widely expressed. Expression is reduced in colorectal cancer cell line SW480 and promyelocytic leukemia cell line HL-60. In interphase cells, it is scattered throughout the nucleoplasm. In mitotic cells, it strongly associates with condensed chromosomes from the prophase to telophase.
Synonyms: KIAA0681, L3MBT, L3MBTL1

Pathways: Chromatin Binding