LYN anticorps

N° du produit ABIN966504

Cité dans 2 publications. Cet anticorps anti-LYN Monoclonal (Clone 2H8D7) (ABIN966504) détecte spécifiquement LYN dans ELISA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour LYN anticorps (ABIN966504)

Antigène: LYN (V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN))

Reactivité: Humain

Hôte: Veuillez nous consulter SVP

Clonalité: Monoclonal

Conjugué: Cet anticorp LYN est non-conjugé

Application: ELISA

Clone: 2H8D7

Détail du produit anti-LYN anticorps

Specificité: Ni-NTA purified truncated recombinant Lyn expressed in E. Coli strain BL21 (DE3).

Purification: Antibodies are purified by protein A affinity chromatography

Immunogène: Ni-NTA purified truncated recombinant Lyn expressed in E.coli strain BL21 (DE3)

Isotype: IgG2b

Information d'application

Indications d'application: ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Format: Liquid

Stock: -20 °C

Références pour anticorps anti-LYN (ABIN966504)

Williams, Wierenga, Saraste: "Insights into Src kinase functions: structural comparisons." dans: Trends in biochemical sciences, Vol. 23, Issue 5, pp. 179-84, (1998) (PubMed).

Hibbs, Dunn: "Lyn, a src-like tyrosine kinase." dans: The international journal of biochemistry & cell biology, Vol. 29, Issue 3, pp. 397-400, (1997) (PubMed).

Détails sur LYN

Antigène: LYN (V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog (LYN))

Autre désignation: LYN

Sujet: Lyn (also known as p53/56 Lyn) is a membrane-associated protein tyrosine kinase (PTK) mostly expressed in hemopoietic cells which is important in cellular signaling. It contains an SH2 and SH3 domain and has been found to be cleaved after activation of caspases in apoptosis. A member of the Src family of PTKs, there are two known isoforms for Lyn which plays an indispensable role in the Fc epsilon RI (Fcer1) and the B-cell IgM receptor signaling pathway and is essential for Syk activation and Lat phosphorylation after Fcer1 aggregation and can also phosphor-ylate Tec on multiple residues. Lyn can also be regulated by IL-2 and IL-3.Lyn is a member of the src family of non-receptor protein tyrosine kinases that is predominantly expressed in haematopoietic tissues. Like all members of the src family, lyn is thought to participate in signal transduction from cell surface receptors that lack intrinsic tyrosine kinase activity. It is associated with a number of cell surface receptors including the B cell antigen receptor and immunoglobulin E receptor (FceRI).

ID gène: 4067

Pathways: Fc-epsilon Receptor Signaling Pathway, Hormone Transport, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling, Integrin Complex, BCR Signaling