MTDH anticorps

N° du produit ABIN966573

Cet anticorps anti-MTDH est un anticorps Souris Monoclonal détectant MTDH dans WB, IHC, ELISA et FACS. Adapté pour Humain. Ce Primary Antibody a été cité dans 4+ publications.

Aperçu rapide pour MTDH anticorps (ABIN966573)

Antigène: MTDH (Metadherin (MTDH))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MTDH est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Clone: 2F11C3

Détail du produit anti-MTDH anticorps

Purification: Antibodies are purified by protein G affinity chromatography.

Immunogène: Purified recombinant fragment of human Metadherin expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
Flow cytometry: 1/200 - 1/400.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 50% glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Références pour anticorps anti-MTDH (ABIN966573)

Hu, Chong, Yang, Wei, Blanco, Li, Reiss, Au, Haffty, Kang: "MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer." dans: Cancer cell, Vol. 15, Issue 1, pp. 9-20, (2008) (PubMed).

Méndez, Audicana, Cancer, Isern, Llaneza, Moreno, Navarro, Tarancón, Valero, Ribas, Jofre, Lucena: "Assessment of drinking water quality using indicator bacteria and bacteriophages." dans: Journal of water and health, Vol. 2, Issue 3, pp. 201-14, (2004) (PubMed).

Britt, Yang, Yang, Flanagan, Callanan, Lim, Lin, Hixson: "Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells." dans: Experimental cell research, Vol. 300, Issue 1, pp. 134-48, (2004) (PubMed).

Brown, Ruoslahti: "Metadherin, a cell surface protein in breast tumors that mediates lung metastasis." dans: Cancer cell, Vol. 5, Issue 4, pp. 365-74, (2004) (PubMed).

Détails sur MTDH

Antigène: MTDH (Metadherin (MTDH))

Autre désignation: Metadherin

Sujet: Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain, blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.
Synonyms: 3D3, AEG1, LYRIC, MTDH

Poids moléculaire: 64kDa

ID gène: 92140

Pathways: Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization