Notch1 anticorps (Notch 1) (N-Term)

Details for Product anti-NOTCH1 Antibody No. ABIN966679, Fournisseur: Connectez-vous pour afficher
Antigène
  • notch1
  • NOTCH1
  • hn1
  • tan1
  • notch
  • xotch
  • xnotch
  • notch-1
  • xnotch1
  • TAN1
  • hN1
  • 9930111A19Rik
  • Mis6
  • N1
  • Tan1
  • lin-12
  • NOTCH
  • Xotch
  • notch1-a
  • notch 1
  • fibropellin-1
  • Notch homolog 1, translocation-associated (Drosophila)
  • Notch homolog 1, translocation-associated
  • notch 1 S homeolog
  • notch1
  • LOC100631526
  • NOTCH1
  • Notch1
  • notch1.S
Épitope
N-Term
70
66
43
23
15
13
8
7
6
6
6
5
5
5
4
4
4
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain
290
255
120
8
6
6
3
2
2
2
1
1
1
1
1
Hôte
Lapin
211
182
13
8
6
2
1
Clonalité
Polyclonal
Conjugué
Cet anticorp Notch1 est non-conjugé
26
18
17
12
10
8
8
7
7
7
5
5
5
5
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC)
264
135
132
97
94
81
63
28
26
16
13
7
5
4
3
3
3
3
2
2
2
2
2
1
1
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to near N-terminal residues of human NOTCH1 (Neurogenic locus notch homolog protein 1)
Autre désignation NOTCH1 (NOTCH1 Antibody Extrait)
Sujet NOTCH1 (Neurogenic locus notch homolog protein 1) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. NOTCH1 affects the implementation of differentiation, proliferation and apoptotic programs. NOTCH1 may be important for normal lymphocyte function. In altered form, NOTCH1 may contribute to transformation or progression in some T-cell neoplasms. NOTCH1 is involved in the maturation of both CD4+ and CD8+ cells in the thymus. NOTCH1 may be important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, may function as a receptor for neuronal DNER and may be involved in the differentiation of Bergmann glia. NOTCH1 is synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane. NOTCH1 truncation is associated with T-cell acute lymphoblastic leukemia.
Synonyms: TAN1(Translocation-associated notch protein TAN-1)
Pathways Signalisation Notch, Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
Restrictions For Research Use only
Produit citée dans: Hambleton, Valeyev, Muranyi, Knott, Werner, McMichael, Handford, Downing: "Structural and functional properties of the human notch-1 ligand binding region." dans: Structure (London, England : 1993), Vol. 12, Issue 12, pp. 2173-83, 2004 (PubMed).

Vardar, North, Sanchez-Irizarry, Aster, Blacklow: "Nuclear magnetic resonance structure of a prototype Lin12-Notch repeat module from human Notch1." dans: Biochemistry, Vol. 42, Issue 23, pp. 7061-7, 2003 (PubMed).

Wu, Sun, Kobayashi, Gao, Griffin: "Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors." dans: Molecular and cellular biology, Vol. 22, Issue 21, pp. 7688-700, 2002 (PubMed).

Gray, Mann, Mitsiadis, Henrique, Carcangiu, Banks, Leiman, Ward, Ish-Horowitz, Artavanis-Tsakonas: "Human ligands of the Notch receptor." dans: The American journal of pathology, Vol. 154, Issue 3, pp. 785-94, 1999 (PubMed).

Matsuno, Eastman, Mitsiades, Quinn, Carcanciu, Ordentlich, Kadesch, Artavanis-Tsakonas: "Human deltex is a conserved regulator of Notch signalling." dans: Nature genetics, Vol. 19, Issue 1, pp. 74-8, 1998 (PubMed).

Ellisen, Bird, West, Soreng, Reynolds, Smith, Sklar: "TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms." dans: Cell, Vol. 66, Issue 4, pp. 649-61, 1991 (PubMed).

Background publications Wu, Aster, Blacklow, Lake, Artavanis-Tsakonas, Griffin: "MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors." dans: Nature genetics, Vol. 26, Issue 4, pp. 484-9, 2000 (PubMed).

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