Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1) anticorps

Détails pour le produit réf. ABIN966704, Fournisseur: Connectez-vous pour afficher
Antigène
  • B23
  • NPM
  • NO38
  • Npm
  • B23NP
  • npm4
  • npm
  • CG7917
  • CRP1
  • Crp1
  • Dmel\\CG7917
  • dNLP
  • dNLP-S
  • p22
  • npm1
  • sb:cb487
  • nucleophosmin 1
  • nucleophosmin (nucleolar phosphoprotein B23, numatrin) L homeolog
  • nucleophosmin 1b
  • Nucleophosmin
  • nucleophosmin
  • nucleophosmin (nucleolar phosphoprotein B23, numatrin)
  • Nucleoplasmin
  • nucleophosmin 1a
  • NPM1
  • Npm1
  • npm1.L
  • npm1b
  • npm
  • Nlp
  • npm1a
Reactivité
Humain, Singe
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174
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20
17
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15
11
10
5
3
3
2
2
1
1
1
1
1
1
Hôte
Souris
255
97
18
1
1
Clonalité (Clone)
Monoclonal ()
Conjugué
Inconjugué
15
11
7
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5
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
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1
Application
Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
312
148
142
96
88
45
42
40
26
19
6
5
4
3
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène Purified recombinant fragment of human NPM expressed in E. Coli.
Clone 7H10B9
Isotype IgG1
Purification Ascitic fluid
Antigène
Autre désignation Nucleophosmin (NPM1 Antibody Extrait)
Sujet Nucleophosmin (NPM), also named B23 or NO38, is a major nucleolar protein which is 20 times more abundant in tumor or proliferating cells than in normal resting cells. NPM has been implicated in several distinct cellular functions, including assembly and transport of ribosomes, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication and molecular chaperoning activities. The NPM is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. The NPM portion contributes to transformation by providing a dimerization domain, which results in activation of the fused kinase.
Synonyms: B23, NPM
Poids moléculaire 33kDa
ID gène 4869
Pathways Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
Indications d'application Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
Immunofluorescence: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C
Produit citée dans: Yoneda-Kato, Look, Kirstein, Valentine, Raimondi, Cohen, Carroll, Morris: "The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1." dans: Oncogene, Vol. 12, Issue 2, pp. 265-75, 1996 (PubMed).

Morris, Kirstein, Valentine, Dittmer, Shapiro, Saltman, Look: "Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma." dans: Science (New York, N.Y.), Vol. 263, Issue 5151, pp. 1281-4, 1994 (PubMed).

Background publications Bullrich, Morris, Hummel, Pileri, Stein, Croce: "Nucleophosmin (NPM) gene rearrangements in Ki-1-positive lymphomas." dans: Cancer research, Vol. 54, Issue 11, pp. 2873-7, 1994 (PubMed).

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