Progesterone Receptor anticorps (PGR) (AA 730-871)

Details for Product anti-PGR Antibody No. ABIN966829, Fournisseur: Connectez-vous pour afficher
Antigène
  • NR3C3
  • PR
  • 9930019P03Rik
  • BB114106
  • ENSMUSG00000074510
  • PR-A
  • PR-B
  • XPR-1
  • pgr
  • xpr-2
  • LOC443444
  • PGR
  • pg
  • pr
  • gb:dq017620
  • progesterone receptor
  • progesterone receptor L homeolog
  • PGR
  • Pgr
  • pgr.L
  • pgr
Épitope
AA 730-871
53
52
40
33
26
19
19
18
18
17
16
15
10
10
9
8
8
8
7
7
7
5
5
5
4
4
3
3
3
3
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Humain
524
93
89
20
11
11
9
6
6
5
4
4
2
1
1
1
1
1
1
1
Hôte
Souris
316
218
3
1
Clonalité (Clone)
Monoclonal ()
Conjugué
Cet anticorp Progesterone Receptor est non-conjugé
17
17
14
9
9
9
2
2
2
2
2
2
2
2
2
2
2
Application
ELISA, Western Blotting (WB)
411
175
146
141
95
48
41
27
21
9
8
5
3
2
2
1
1
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène Purified recombinant fragment of PGR (aa730-871) expressed in E. Coli.
Clone 8A11H1
Isotype IgG1
Purification Ascitic fluid
Autre désignation PGR (PGR Antibody Extrait)
Sujet PGR: progesterone receptor. This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform A only, and mediate their own response genes and physiologic effects with little overlap. The location of transcription initiation for isoform B has not been clearly determined.
Synonyms: PR, NR3C3, PGR
ID gène 5241
Pathways Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Smooth Muscle Cell Migration
Indications d'application Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C
Background publications Yin, Lin, Cheng, Marsh, Utsunomiya, Ishikawa, Xue, Reierstad, Innes, Thung, Kim, Xu, Bulun: "Progesterone receptor regulates Bcl-2 gene expression through direct binding to its promoter region in uterine leiomyoma cells." dans: The Journal of clinical endocrinology and metabolism, Vol. 92, Issue 11, pp. 4459-66, 2007 (PubMed).

Tung, Abdel-Hafiz, Shen, Harvell, Nitao, Richer, Sartorius, Takimoto, Horwitz: "Progesterone receptors (PR)-B and -A regulate transcription by different mechanisms: AF-3 exerts regulatory control over coactivator binding to PR-B." dans: Molecular endocrinology (Baltimore, Md.), Vol. 20, Issue 11, pp. 2656-70, 2006 (PubMed).

Produit citée dans: Polo, José Galindo, Martínez, Alvarez, Arévalo, Asensi, Cánoves, Cáncer, Collazos, Estrada, Gómez-Candela, Johnston, Locutura, López-Aldeguer, Lozano, Miralles, Muñoz-Sanz, Ortega, Pascua, Pedrol, Pulido, San Martín, Sanz, Viciana, Chamorro,: "[Recommendations of the Study Group for Metabolic Alterations/Secretariat for the National AIDS Plan (GEAM/SPNS) on the management of metabolic and morphologic alterations in patients with HIV infection]." dans: Enfermedades infecciosas y microbiología clínica, Vol. 24, Issue 2, pp. 96-117, 2006 (PubMed).

Buser, Gass-Handel, Wyszomierski, Doppler, Leonhardt, Schaack, Rosen, Watkin, Anderson, Edwards: "Progesterone receptor repression of prolactin/signal transducer and activator of transcription 5-mediated transcription of the beta-casein gene in mammary epithelial cells." dans: Molecular endocrinology (Baltimore, Md.), Vol. 21, Issue 1, pp. 106-25, 2006 (PubMed).

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