SIRT6 anticorps (C-Term)

N° du produit ABIN967032

Cité dans 3+ publications. Cet anticorps anti-SIRT6 est un anticorps Polyclonal produit chez le Lapin, détectant SIRT6 dans IHC. Convient pour Humain.

Aperçu rapide pour SIRT6 anticorps (C-Term) (ABIN967032)

Antigène: SIRT6 (Sirtuin 6 (SIRT6))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIRT6 est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-SIRT6 anticorps

Épitope: C-Term

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human SIRT6 (Mono-ADP-ribosyltransferase sirtuin-6)

Information d'application

Restrictions: For Research Use only

Stockage

Stock: 4 °C

Références pour anticorps anti-SIRT6 (ABIN967032)

Kawahara, Michishita, Adler, Damian, Berber, Lin, McCord, Ongaigui, Boxer, Chang, Chua: "SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span." dans: Cell, Vol. 136, Issue 1, pp. 62-74, (2009) (PubMed).

Michishita, McCord, Berber, Kioi, Padilla-Nash, Damian, Cheung, Kusumoto, Kawahara, Barrett, Chang, Bohr, Ried, Gozani, Chua: "SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin." dans: Nature, Vol. 452, Issue 7186, pp. 492-6, (2008) (PubMed).

Kanfi, Shalman, Peshti, Pilosof, Gozlan, Pearson, Lerrer, Moazed, Marine, de Cabo, Cohen: "Regulation of SIRT6 protein levels by nutrient availability." dans: FEBS letters, Vol. 582, Issue 5, pp. 543-8, (2008) (PubMed).

Détails sur SIRT6

Antigène: SIRT6 (Sirtuin 6 (SIRT6))

Autre désignation: SIRT6

Sujet: SIRT6 (Mono-ADP-ribosyltransferase sirtuin-6) is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined, however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. SIRT6 (Mono-ADPribosyltransferase sirtuin-6) is included in class IV of the sirtuin family. SIRT6 (Mono-ADPribosyltransferase sirtuin-6) contains 1 deacetylase sirtuin-type domain.
Synonyms: SIR2L6(SIR2-like protein 6)