SLUG anticorps (C-Term)

N° du produit ABIN967057

Cet anticorps Lapin Polyclonal détecte spécifiquement SLUG dans IHC. Il présente une réactivité envers Humain, Souris et Rat et a été mentionné dans 5+ publications.

Aperçu rapide pour SLUG anticorps (C-Term) (ABIN967057)

Antigène: SLUG (SNAI2) (Snail Family Zinc Finger 2 (SNAI2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLUG est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-SLUG anticorps

Épitope: C-Term

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to near C-terminal residues of human SNAI2

Information d'application

Restrictions: For Research Use only

Stockage

Stock: 4 °C

Références pour anticorps anti-SLUG (ABIN967057)

Larriba, Martín-Villar, García, Pereira, Peña, de Herreros, Bonilla, Muñoz: "Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer." dans: Carcinogenesis, Vol. 30, Issue 8, pp. 1459-68, (2009) (PubMed).

Wang, Wang, Chang, Wu, Chao, Kao, Yuan, Lin, Yang, Chan, Li, Hong, Yang: "p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug." dans: Nature cell biology, Vol. 11, Issue 6, pp. 694-704, (2009) (PubMed).

Saegusa, Hashimura, Kuwata, Okayasu: "Requirement of the Akt/beta-catenin pathway for uterine carcinosarcoma genesis, modulating E-cadherin expression through the transactivation of slug." dans: The American journal of pathology, Vol. 174, Issue 6, pp. 2107-15, (2009) (PubMed).

Hemavathy, Guru, Harris, Chen, Ip: "Human Slug is a repressor that localizes to sites of active transcription." dans: Molecular and cellular biology, Vol. 20, Issue 14, pp. 5087-95, (2000) (PubMed).

Inukai, Inoue, Kurosawa, Goi, Shinjyo, Ozawa, Mao, Inaba, Look: "SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein." dans: Molecular cell, Vol. 4, Issue 3, pp. 343-52, (1999) (PubMed).

Détails sur SLUG

Antigène: SLUG (SNAI2) (Snail Family Zinc Finger 2 (SNAI2))

Autre désignation: SNAI2

Sujet: SNAI2 is a member of the Snail family of C2H2-type zinc finger transcription factors. The SNAI2 protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress Ecadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this SNAI2 gene may be associated with sporatic cases of neural tube defects.
Synonyms: MGC10182, SLUG, SLUGH1, WS2D