SRA1 anticorps

N° du produit ABIN967076

Il existe 3+ publications pour ce produit. L’anticorps anti-SRA1 Monoclonal est utilisé pour la détection de SRA1 dans des échantillons de Humain. Il a été validé pour WB, ELISA et IHC.

Aperçu rapide pour SRA1 anticorps (ABIN967076)

Antigène: SRA1 (Steroid Receptor RNA Activator 1 (SRA1))

Reactivité: Humain

Hôte: Veuillez nous consulter SVP

Clonalité: Monoclonal

Conjugué: Cet anticorp SRA1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-SRA1 anticorps

Specificité: Ni-NTA purified truncated recombinant SRA expressed in E. Coli strain BL21 (DE3)

Purification: Crude ascites.

Isotype: IgG1

Information d'application

Indications d'application: Western Blot: 1: 500- 1: 2,000
IHC(P): 1: 500- 1: 2,000
IHC(F): 1: 500- 1: 2,000
ELISA: Propose dilution 1: 10,000 Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Format: Liquid

Stock: -20 °C

Références pour anticorps anti-SRA1 (ABIN967076)

Chooniedass-Kothari, Hamedani, Troup, Hubé, Leygue: "The steroid receptor RNA activator protein is expressed in breast tumor tissues." dans: International journal of cancer. Journal international du cancer, Vol. 118, Issue 4, pp. 1054-9, (2006) (PubMed).

Chooniedass-Kothari, Emberley, Hamedani, Troup, Wang, Czosnek, Hube, Mutawe, Watson, Leygue: "The steroid receptor RNA activator is the first functional RNA encoding a protein." dans: FEBS letters, Vol. 566, Issue 1-3, pp. 43-7, (2004) (PubMed).

Lanz, Chua, Barron, Söder, DeMayo, OMalley: "Steroid receptor RNA activator stimulates proliferation as well as apoptosis in vivo." dans: Molecular and cellular biology, Vol. 23, Issue 20, pp. 7163-76, (2003) (PubMed).

Détails sur SRA1

Antigène: SRA1 (Steroid Receptor RNA Activator 1 (SRA1))

Autre désignation: SRA

Sujet: Steroid receptor RNA activator 1 (SRA), with 237-amino acid protein (about 27kDa), belongs to the growing family of functional non-coding RNAs. SRA was originally described as the first functional noncoding RNA able to specifically coactivate the activity of steroid receptors. Specifically, SRA exists as both an RNA transcript that forms a complex with steroid receptor coactivator-1 and as a stably expressed protein. Its expression is strongly up-regulated in many human tumors of the breast, uterus, and ovary, suggesting a potential role in pathogenesis. Although coactivation of steroid-dependent transcription by SRA is accompanied by a proliferative response, overexpression is not in itself sufficient to induce turmorigenesis.

ID gène: 10011

Pathways: EGFR Signaling Pathway, Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development