TEK anticorps (Extracellular Domain)

N° du produit ABIN967565

L’anticorps Souris Monoclonal anti-TEK a été validé pour WB et IHC (fro). Il convient pour détecter TEK dans des échantillons de Humain et Souris. Il y a 4+ publications disponibles.

Aperçu rapide pour TEK anticorps (Extracellular Domain) (ABIN967565)

Antigène: TEK (TEK Tyrosine Kinase, Endothelial (TEK))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TEK est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 33

Détail du produit anti-TEK anticorps

Épitope: Extracellular Domain

Marque: BD Pharmingen™

Réactivité croisée: Souris

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3. Please refer to us for technical protocols.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human TIE2 extracellular domain Recombinant Protein

Isotype: IgG1 kappa

Information d'application

Commentaires:

Related Products: ABIN967389, ABIN968537

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-TEK (ABIN967565)

Partanen, Dumont: "Functions of Tie1 and Tie2 receptor tyrosine kinases in vascular development." dans: Current topics in microbiology and immunology, Vol. 237, Issue 4, pp. 159-72, (1999) (PubMed).

Peters, Coogan, Berry, Marks, Iglehart, Kontos, Rao, Sankar, Trogan: "Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis." dans: British journal of cancer, Vol. 77, Issue 1, pp. 51-6, (1998) (PubMed).

Wong, Haroon, Werner, Dewhirst, Greenberg, Peters: "Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues." dans: Circulation research, Vol. 81, Issue 4, pp. 567-74, (1997) (PubMed).

Dumont, Gradwohl, Fong, Puri, Gertsenstein, Auerbach, Breitman: "Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo." dans: Genes & development, Vol. 8, Issue 16, pp. 1897-909, (1994) (PubMed).

Détails sur TEK

Antigène: TEK (TEK Tyrosine Kinase, Endothelial (TEK))

Autre désignation: TIE2

Sujet: The TIE receptor family is a member of the class of receptors called the receptor tyrosine kinases (RKT). RKTs are cell surface receptors which also contain a protein kinase domain in their intracellular portion and upon binding of their specific growth factor, initiate a series of downstream biological events. TIE receptors, designated Tie1 and Tie2 (Tek) have a tissue distribution which is limited primarily to cells of endothelial origin. Tie2 has been shown to be required for the normal development of vascular structures during embryogenesis. It has also been demonstrated to play a role in normal and pathological angiogenesis in adults. Tie2 has a predicted molecular weight of 126 kD, but may be observable at ~130-165 kDa. This antibody has been reported to recognize human and mouse Tie2 but not Tie1.

Poids moléculaire: 130-165 kDa

Pathways: Signalisation RTK, Growth Factor Binding